Plasma Phospholipid Polyunsaturated Fatty Acid Associations with Neurocognition.
Plasma Phospholipid Polyunsaturated Fatty Acid Associations with Neurocognition.
复制标题
血浆磷脂多不饱和脂肪酸与神经认知的关联。
DOI：
10.3390/nu15214542
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发表时间：
2023-10-26
期刊：
影响因子：
5.9
通讯作者：
Sublette ME
中科院分区：
文献类型：
--
作者：
Ling J;Keilp JG;Galfalvy HC;Cardino VN;Ahmed A;Burke AK;Fenton JI;Mann JJ;Sublette ME
神经认知缺陷与重度抑郁症（MDD）和自杀行为有关，认知功能可能受到血液中多不饱和脂肪酸（PUFA）水平的影响。已经描述了ω-3（n-3）PUFA的神经保护功能，而ω-6（n-6）PUFA表现出广泛相反的活性。这两类PUFA都与MDD和自杀行为有关。然而，很少有研究调查PUFA和神经认知功能之间的关系，就MDD或自杀行为。在MDD（n = 45）和健康志愿者（HV，n = 30）中，我们评估了注意力和执行功能任务的表现及其与血浆磷脂PUFA水平的关系，以二十碳五烯酸（EPA%），二十二碳六烯酸（DHA%）和花生四烯酸（AA%）占总血浆磷脂的百分比表示。回归模型测试PUFA水平和三组任务表现之间的相关性：有自杀企图史的MDD（SA，n = 20），没有自杀企图的MDD（NA，n = 25）和HV。交互测试表明，在NA组中，EPA%与持续表现测试分数呈显著正相关（F = 4.883，df = 2.72，p = 0.01），持续注意力的测量。AA%与两项执行功能任务的表现呈负相关，即物体交替（beta =-3.97，z-score =-2.67，p = 0.008）和威斯康星州卡片分类（beta = 0.80，t-score =-2.16，df = 69，p = 0.035），调整组和年龄后，无组效应。我们的研究结果表明PUFA不平衡在注意功能和执行性能中的作用;然而，没有观察到MDD特异性效应。
Neurocognitive deficits are implicated in major depressive disorder (MDD) and suicidal behavior, and cognitive function may be affected by blood levels of polyunsaturated fatty acids (PUFAs). Neuroprotective functions have been described for omega-3 (n-3) PUFAs, while omega-6 (n-6) PUFAs exhibit broadly opposing activities. Both classes of PUFAs are linked to MDD and suicidal behavior. However, few studies have investigated the relationships between PUFAs and neurocognitive function with respect to MDD or suicidal behavior. Among participants with MDD (n = 45) and healthy volunteers (HV, n = 30) we assessed performance on tasks of attentional capacity and executive function and its relationship to plasma phospholipid PUFA levels, expressed as a percentage of total plasma phospholipids, for eicosapentaenoic acid (EPA%), docosahexaenoic acid (DHA%), and arachidonic acid (AA%). Regression models tested the correlations between PUFA levels and task performance in three groups: MDD with a history of suicide attempt (SA, n = 20), MDD with no attempts (NA, n = 25), and HV. Interaction testing indicated a significant positive correlation of EPA% with continuous performance test scores in the NA group (F = 4.883, df = 2,72, p = 0.01), a measure of sustained attention. The AA% correlated negatively with performance on two executive function tasks, object alternation (beta = −3.97, z-score = −2.67, p = 0.008) and the Wisconsin card sort (beta = 0.80, t-score = −2.16, df = 69, p = 0.035), after adjustment for group and age, with no group effects. Our findings suggest a role for PUFA imbalance in attentional functioning and executive performance; however, no MDD-specific effect was observed.
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影响因子：
2.9
作者：
Gertsik L;Poland RE;Bresee C;Rapaport MH
通讯作者：
Rapaport MH
影响因子：
7.1
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.
影响因子：
3.7
作者：
Glaser, Claudia;Demmelmair, Hans;Koletzko, Berthold
通讯作者：
Koletzko, Berthold
影响因子：
4.1
作者：
Antypa, Niki;Smelt, August H. M.;Van der Does, A. J. Willem
通讯作者：
Van der Does, A. J. Willem
DOI：
10.1002/syn.22018
发表时间：
2018-03
期刊：
Synapse (New York, N.Y.)
影响因子：
--
作者：
Zanderigo F;Kang Y;Kumar D;Nikolopoulou A;Mozley PD;Kothari PJ;He B;Schlyer D;Rapoport SI;Oquendo MA;Vallabhajosula S;Mann JJ;Sublette ME
通讯作者：
Sublette ME