Perilimbal sclera mechanical properties: Impact on intraocular pressure in porcine eyes.
Perilimbal sclera mechanical properties: Impact on intraocular pressure in porcine eyes.
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DOI：
10.1371/journal.pone.0195882
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Argento A
中科院分区：
文献类型：
--
作者：
Man X;Arroyo E;Dunbar M;Reed DM;Shah N;Kagemann L;Kim W;Moroi SE;Argento A
人们对后巩膜生物力学和眼压（IOP）负荷与青光眼性视神经病变之间的关系有广泛的了解；然而，角膜缘周围巩膜组织对房水引流通路（包括远端静脉流出系统）和眼压调节的生物力学影响的作用尚不完全清楚。这项工作的目的是研究灌注猪眼的流出特性与角膜缘周围巩膜、后巩膜和角膜生物力学特性的关系。将来自 11 只不同动物的去核猪眼以两种固定流速灌注替代水，同时监测它们的眼压。灌注后，对来自同一灌注眼的角膜缘周围巩膜、后巩膜和角膜样本进行机械应力应变和松弛测试。数据统计分析表明，角膜缘周围巩膜组织切线模量增加与灌注 IOP 增加之间存在很强的相关性（较低流速时 R2 = 0.74，p = 0.0006，较高流速时 R2 = 0.71，p = 0.0011）。相反，眼压与其他组织的切线模量（后巩膜：较低流速时 R2 = 0.17，较高流速时 R2 = 0.30；角膜：较低流速时 R2 = 0.02，较高流速时 R2<0.01）以及任何组织的粘弹性特性之间不存在显着相关性（所有情况下 R2 ≤ 0.08）。此外，IOP 而非净流出设施存在相关性（所有情况下 R2 ≤ 0.12）。这些结果提供了新的证据，表明灌注猪眼中的眼压受到巩膜最前部（即角膜缘）的切线模量（有时称为组织刚度）的强烈影响。
There is extensive knowledge on the relationship of posterior scleral biomechanics and intraocular pressure (IOP) load on glaucomatous optic neuropathy; however, the role for biomechanical influence of the perilimbal scleral tissue on the aqueous humor drainage pathway, including the distal venous outflow system, and IOP regulation is not fully understood. The purpose of this work is to study the outflow characteristics of perfused porcine eyes relative to the biomechanical properties of the perilimbal sclera, the posterior sclera and the cornea. Enucleated porcine eyes from eleven different animals were perfused with surrogate aqueous at two fixed flow rates while monitoring their IOP. After perfusion, mechanical stress-strain and relaxation tests were conducted on specimens of perilimbal sclera, posterior sclera, and cornea from the same perfused eyes. Statistical analysis of the data demonstrated a strong correlation between increased tangent modulus of the perilimbal sclera tissues and increased perfusion IOP (R2 = 0.74, p = 0.0006 at lower flow rate and R2 = 0.71, p = 0.0011 at higher flow rate). In contrast, there were no significant correlations between IOP and the tangent modulus of the other tissues (Posterior sclera: R2 = 0.17 at lower flow rate and R2 = 0.30 at higher flow rate; cornea: R2 = 0.02 at lower flow rate and R2<0.01 at higher flow rate) nor the viscoelastic properties of any tissue (R2 ≤ 0.08 in all cases). Additionally, the correlation occurred for IOP and not net outflow facility (R2 ≤ 0.12 in all cases). These results provide new evidence that IOP in perfused porcine eyes is strongly influenced by the tangent modulus, sometimes called the tissue stiffness, of the most anterior portion of the sclera, i.e. the limbus.
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影响因子：
2.4
作者：
Billiar, KL;Sacks, MS
通讯作者：
Sacks, MS
DOI：
10.1115/1.4006089
发表时间：
2012-03-01
影响因子：
1.7
作者：
Boschetti, F.;Triacca, V.;Pandolfi, A.
通讯作者：
Pandolfi, A.
影响因子：
4.4
作者：
Ivers KM;Yang H;Gardiner SK;Qin L;Reyes L;Fortune B;Burgoyne CF
通讯作者：
Burgoyne CF
影响因子：
3.4
作者：
Lari, David R.;Schultz, David S.;Wang, Aaron S.;Lee, On-Tat;Stewart, Jay M.
通讯作者：
Stewart, Jay M.
影响因子：
3.4
作者：
Kimball, Elizabeth C.;Nguyen, Cathy;Steinhart, Matthew R.;Nguyen, Thao D.;Pease, Mary E.;Oglesby, Ericka N.;Oveson, Brian C.;Quigley, Harry A.
通讯作者：
Quigley, Harry A.