Potential chemotherapy side effects: what do oncologists tell parents?
Potential chemotherapy side effects: what do oncologists tell parents?
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DOI：
10.1002/pbc.21835
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发表时间：
2009-04
影响因子：
3.2
通讯作者：
Kodish, Eric
中科院分区：
文献类型：
--
作者：
Ramirez, Lisa Ysela;Huestis, Samantha E.;Yap, Tsiao Yi;Zyzanski, Stephen;Drotar, Dennis;Kodish, Eric
为了确定急性白血病诊断后的知情同意会议（ICC）中讨论的短期副作用和晚期副作用的数量，我们观察了ICC期间短期副作用与晚期副作用的发生率和比例。在六个不同的研究地点对儿童白血病试验的ICC(s)进行录音。对每个ICC过程中提到的副作用进行了编码和分析。我们回顾了140个病例，从中我们编码了3173个急性副作用和242个晚期副作用。每次ICC期间提到的平均总副作用为24（范围5-47）。编码的晚期副作用数量明显少于急性副作用。我们还发现，ICC(s)的持续时间与提到的副作用数量呈正相关。此外，提到的总副作用的频率与患者或父母的人口统计学因素无关。我们的研究结果表明，急性副作用经常被提及，但对早期ICC(s)的晚期效应的讨论要少得多。在知情同意会议中，仔细考虑与家长沟通的急性和晚期反应的比例，可以促进家长对临床相关副作用的理解。
In order to determine the number of short-term side effects and late effects discussed during an informed consent conference (ICC) after the diagnosis of acute leukemia, we observed the occurrence(s) and the ratio between short-term side effects versus late effects during an ICC. ICC(s) of childhood leukemia trials were audio-taped at six different study sites. The side effects mentioned during each of these ICC(s) were coded and analyzed. One hundred and forty cases were reviewed, from which we coded a total of 3173 acute side effects and 242 late effects. The mean total side effects mentioned during each ICC was 24 (range 5-47). The number of late effects coded were significantly less than acute side effects. We also found that the duration of ICC(s) was positively correlated with the number of side effects mentioned. In addition, the frequency of total side effects mentioned was independent of patient or parent demographic factors. Our results show that acute side effects are often mentioned but the discussion of late effects is much less frequent in the initial ICC(s). Careful consideration regarding the ratio of acute and late effects that are communicated to parents in the context of the informed consent conference may facilitate parental understanding of clinically relevant side effects.
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DOI：
10.1001/archpedi.1984.02140450031010
发表时间：
1984-01-01
影响因子：
--
作者：
GREENBERG, LW;JEWETT, LS;LIPNICK, RN
通讯作者：
LIPNICK, RN
影响因子：
3.2
作者：
Abbe, Marisa;Simon, Christian;Kodish, Eric D.
通讯作者：
Kodish, Eric D.
影响因子：
3.6
作者：
EISER, C;PARKYN, T;MCNINCH, A
通讯作者：
MCNINCH, A
影响因子：
45.3
作者：
Greenley, RN;Drotar, D;Kodish, E
通讯作者：
Kodish, E
影响因子：
4.1
作者：
Palmboom, G. G.;Willems, D. L.;de Haes, J. C. J. M.
通讯作者：
de Haes, J. C. J. M.