The fornix in mild cognitive impairment and Alzheimer's disease.
The fornix in mild cognitive impairment and Alzheimer's disease.
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DOI：
10.3389/fnagi.2015.00001
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发表时间：
2015
影响因子：
4.8
通讯作者：
Rosenberg PB
中科院分区：
文献类型：
--
作者：
Nowrangi MA;Rosenberg PB
穹窿是位于间脑内侧的完整白质束，是边缘结构的一部分。它在记忆功能中发挥着至关重要的作用，因此已成为阿尔茨海默病（AD）和轻度认知障碍（MCI）近期研究重点的主题。随着 AD 特征性病理过程的进展，内侧颞叶和其他区域的结构和功能变化在临床症状出现前数年就变得明显。尽管灰质萎缩的研究最多，但白质结构（尤其是穹窿）的退化可能先于这些退化，并且可以通过使用扩散张量成像（DTI）和其他互补成像技术来检测。最近利用穹窿 DTI 测量的研究表明，诊断组具有良好的区分性，特别是早期和临床前，以及对 MCI 和 AD 事件的预测能力。由于药物治疗发展缓慢，通过 DBS 刺激和调节穹窿功能一直是一个令人兴奋的新领域。
The fornix is an integral white matter bundle located in the medial diencephalon and is part of the limbic structures. It serves a vital role in memory functions and as such has become the subject of recent research emphasis in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). As the characteristic pathological processes of AD progress, structural and functional changes to the medial temporal lobes and other regions become evident years before clinical symptoms are present. Though gray matter atrophy has been the most studied, degradation of white matter structures especially the fornix may precede these and has become detectable with use of diffusion tensor imaging (DTI) and other complimentary imaging techniques. Recent research utilizing DTI measurement of the fornix has shown good discriminability of diagnostic groups, particularly early and preclinical, as well as predictive power for incident MCI and AD. Stimulating and modulating fornix function by the way of DBS has been an exciting new area as pharmacological therapeutics has been slow to develop.
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影响因子：
9.9
作者：
Cash DM;Ridgway GR;Liang Y;Ryan NS;Kinnunen KM;Yeatman T;Malone IB;Benzinger TL;Jack CR Jr;Thompson PM;Ghetti BF;Saykin AJ;Masters CL;Ringman JM;Salloway SP;Schofield PR;Sperling RA;Cairns NJ;Marcus DS;Xiong C;Bateman RJ;Morris JC;Rossor MN;Ourselin S;Fox NC;Dominantly Inherited Alzheimer Network (DIAN)
通讯作者：
Dominantly Inherited Alzheimer Network (DIAN)
影响因子：
2.8
作者：
Bilir, E;Craven, W;Kuzniecky, R
通讯作者：
Kuzniecky, R
影响因子：
4.2
作者：
Gold BT;Zhu Z;Brown CA;Andersen AH;LaDu MJ;Tai L;Jicha GA;Kryscio RJ;Estus S;Nelson PT;Scheff SW;Abner E;Schmitt FA;Van Eldik LJ;Smith CD
通讯作者：
Smith CD
影响因子：
4
作者：
Fontaine, Denys;Deudon, Audrey;Robert, Philippe
通讯作者：
Robert, Philippe
影响因子：
3.1
作者：
Boespflug, Erin L.;Storrs, Judd;Krikorian, Robert
通讯作者：
Krikorian, Robert