Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear.
Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear.
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DOI：
10.1186/s12891-017-1789-5
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发表时间：
2017-11-09
影响因子：
2.3
通讯作者：
Lovering RM
中科院分区：
文献类型：
--
作者：
Valencia AP;Iyer SR;Spangenburg EE;Gilotra MN;Lovering RM
肩袖（RTC）撕裂是导致肌肉不良变化的常见临床问题，但将组织病理学与收缩功能进行比较的信息有限。本研究评估了大鼠RTC撕裂模型的冈上肌力量和对损伤的敏感性，并将这些功能变化与肌肉的组织病理学进行了比较。通过冈上肌和冈下肌的腱切断术在雄性大鼠中诱导单侧RTC撕裂。在肌腱切断术后第2天和第15天，在体内测量冈上肌的最大强直力和对损伤的敏感性。对冈上肌称重并收获用于神经肌肉接头（NMJ）、肌内脂质和胶原的组织学分析。肌腱切开术最终导致萎缩和虚弱。尽管在第2天肌肉质量没有损失，但收缩力降低了30%，NMJ连续性和大小降低。在第15天，肌肉萎缩明显但NMJ形态恢复的时间点，力持续降低。在第15天，撕裂的肌肉胶原蛋白堆积密度降低，也更容易受到收缩引起的损伤。肌肉大小和组织病理学不是整体RTC收缩健康的直接指标。NMJ形态和胶原组织的变化与收缩功能的变化相关，因此可能在对损伤的反应中发挥作用。虽然我们的研究结果仅限于RTC撕裂后的急性期，但最突出的发现是RTC肌腱切断术导致冈上肌损伤的易感性增加。
Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle. Unilateral RTC tears were induced in male rats via tenotomy of the supraspinatus and infraspinatus. Maximal tetanic force and susceptibility to injury of the supraspinatus muscle were measured in vivo at day 2 and day 15 after tenotomy. Supraspinatus muscles were weighed and harvested for histologic analysis of the neuromuscular junction (NMJ), intramuscular lipid, and collagen. Tenotomy resulted in eventual atrophy and weakness. Despite no loss in muscle mass at day 2 there was a 30% reduction in contractile force, and a decrease in NMJ continuity and size. Reduced force persisted at day 15, a time point when muscle atrophy was evident but NMJ morphology was restored. At day 15, torn muscles had decreased collagen-packing density and were also more susceptible to contraction-induced injury. Muscle size and histopathology are not direct indicators of overall RTC contractile health. Changes in NMJ morphology and collagen organization were associated with changes in contractile function and thus may play a role in response to injury. Although our findings are limited to the acute phase after a RTC tear, the most salient finding is that RTC tenotomy results in increased susceptibility to injury of the supraspinatus.
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影响因子：
5.5
作者：
Gigliotti, Deanna;Leiter, Jeff R. S.;Anderson, Judy E.
通讯作者：
Anderson, Judy E.
DOI：
10.1152/ajpregu.00483.2006
发表时间：
2007-02-01
影响因子：
2.8
作者：
Arruda, Ellen M.;Mundy, Kevin;Baar, Keith
通讯作者：
Baar, Keith
影响因子：
5.5
作者：
BROOKS, SV;ZERBA, E;FAULKNER, JA
通讯作者：
FAULKNER, JA
影响因子：
2.8
作者：
Davies, Michael R.;Ravishankar, Bharat;Feeley, Brian T.
通讯作者：
Feeley, Brian T.
影响因子：
3
作者：
Gumucio, Jonathan P.;Korn, Michael A.;Saripalli, Anjali L.;Flood, Michael D.;Phan, Anthony C.;Roche, Stuart M.;Lynch, Evan B.;Claflin, Dennis R.;Bedi, Asheesh;Mendias, Christopher L.
通讯作者：
Mendias, Christopher L.