NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph.
NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph.
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DOI：
10.1088/0031-9155/58/11/3791
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发表时间：
2013-06-07
影响因子：
3.5
通讯作者：
Chatziioannou AF
中科院分区：
文献类型：
--
作者：
Gu Z;Taschereau R;Vu NT;Wang H;Prout DL;Silverman RW;Bai B;Stout DB;Phelps ME;Chatziioannou AF
PETbox 4是一款全新的全断层台式PET扫描仪，专用于对小鼠进行高灵敏度和高分辨率成像。该手稿使用美国电气制造商协会（NEMA）NU 4-2008标准表征原型系统的性能，包括灵敏度、空间分辨率、能量分辨率、散射分数、计数率性能和图像质量的研究。还将PETbox 4的性能与上一代有限角度断层扫描系统PETbox的性能进行了比较。PETbox 4由四个相对的平板型探测器组成，以盒状几何形状排列。每个面板由1.82 × 1.82 × 7 mm锗酸铋（BGO）闪烁晶体的24 × 50像素阵列制成，晶体间距为1.90mm。这些闪烁阵列中的每一个通过玻璃光导耦合到两个Hamamatsu H8500光电倍增管。采用最大似然期望最大化（ML-EM）算法重建45 × 45 × 95 mm视场（FOV）的体积图像，该算法结合了基于参数化探测器响应的系统模型。在150-650 keV的能量窗口下，在FOV中心处的峰值绝对灵敏度约为18%。测量的晶体能量分辨率范围为13.5%至48.3%半高宽（FWHM），平均为18.0%。本征探测器的空间分辨率在横向和轴向方向上均为1.5mm FWHM。FOV中不同位置的重建图像空间分辨率范围为1.32 mm至1.93 mm，平均为1.46 mm。对于1.5 MBq（40 µCi）的总活度，小鼠大小的体模的峰值噪声等效计数率为35 kcps，散射分数为28%。图像质量体模均匀区域的标准差为5.7%。回收系数范围为0.10 ~ 0.93。与第一代双面板PETbox系统相比，PETbox 4在灵敏度和空间分辨率上实现了实质性的改进。整体性能表明，PETbox 4扫描仪适合为基于分子成像的生物医学研究生成高质量图像。
PETbox4 is a new, fully tomographic bench top PET scanner dedicated to high sensitivity and high resolution imaging of mice. This manuscript characterizes the performance of the prototype system using the National Electrical Manufacturers Association (NEMA) NU 4–2008 standards, including studies of sensitivity, spatial resolution, energy resolution, scatter fraction, count-rate performance and image quality. The PETbox4 performance is also compared with the performance of PETbox, a previous generation limited angle tomography system. PETbox4 consists of four opposing flat-panel type detectors arranged in a box like geometry. Each panel is made by a 24 × 50 pixelated array of 1.82 × 1.82 × 7mm bismuth germanate (BGO) scintillation crystals with a crystal pitch of 1.90mm. Each of these scintillation arrays is coupled to two Hamamatsu H8500 photomultiplier tubes via a glass light guide. Volumetric images for a 45 × 45 × 95 mm field of view (FOV) are reconstructed with a maximum likelihood expectation maximization (ML-EM) algorithm incorporating a system model based on a parameterized detector response. With an energy window of 150–650 keV, the peak absolute sensitivity is approximately 18% at the center of FOV. The measured crystal energy resolution ranges from 13.5% to 48.3% full width at half maximum (FWHM), with a mean of 18.0%. The intrinsic detector spatial resolution is 1.5mm FWHM in both transverse and axial directions. The reconstructed image spatial resolution for different locations in the FOV ranges from 1.32mm to 1.93 mm, with an average of 1.46 mm. The peak noise equivalent count rate for the mouse-sized phantom is 35 kcps for a total activity of 1.5 MBq (40 µCi) and the scatter fraction is 28%. The standard deviation in the uniform region of the image quality phantom is 5.7%. The recovery coefficients range from 0.10 to 0.93. In comparison to the first generation two panel PETbox system, PETbox4 achieves substantial improvements on sensitivity and spatial resolution. The overall performance demonstrates that the PETbox4 scanner is suitable for producing high quality images for molecular imaging based biomedical research.
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影响因子：
1.8
作者：
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