Plant perception of β-aminobutyric acid is mediated by an aspartyl-tRNA synthetase.
Plant perception of β-aminobutyric acid is mediated by an aspartyl-tRNA synthetase.
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DOI：
10.1038/nchembio.1520
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发表时间：
2014-06
影响因子：
14.8
通讯作者：
Ton, Jurriaan
中科院分区：
文献类型：
--
作者：
Luna, Estrella;van Hulten, Marieke;Zhang, Yuhua;Berkowitz, Oliver;Lopez, Ana;Petriacq, Pierre;Sellwood, Matthew A.;Chen, Beining;Burrell, Mike;van de Meene, Allison;Pieterse, Corne M. J.;Flors, Victor;Ton, Jurriaan
特定的化学物质可以启动植物免疫系统，增强防御能力。β-氨基丁酸（BABA）是一种引发剂，可提供广谱疾病保护。然而，BABA在高剂量施用时也抑制植物生长，这阻碍了其作为作物防御激活剂的应用。在这里，我们描述了一个突变体拟南芥，是受损的ABA诱导的疾病免疫（ibi 1），但过敏的ABA诱导的生长抑制。IBI编码一种乙酰-tRNA合成酶。对映体特异性结合的R-BABA IBI 1引发蛋白质的非典型防御信号在病原体攻击后的细胞质中。这种引发与天冬氨酸积累和tRNA诱导的翻译起始因子eIF 2 α磷酸化有关。而eIF 2 α磷酸化GCN 2激酶的突变不影响BABA诱导的免疫应答，但可解除BABA诱导的生长抑制。因此，BABA激活的IBI 1通过不同的途径控制植物免疫和生长。我们的研究结果为将广谱抗病性与植物生长的相关成本分开提供了新的机会。
Specific chemicals can prime the plant immune system for augmented defence. β-aminobutyric acid (BABA) is a priming agent that provides broad-spectrum disease protection. However, BABA also suppresses plant growth when applied in high doses, which has hampered its application as a crop defence activator. Here we describe a mutant of Arabidopsis thaliana that is impaired in BABA-induced disease immunity (ibi1) but hypersensitive to BABA-induced growth repression. IBI encodes an aspartyl-tRNA synthetase. Enantiomer-specific binding of R-BABA to IBI1 primed the protein for non-canonical defence signalling in the cytoplasm after pathogen attack. This priming was associated with aspartic acid accumulation and tRNA-induced phosphorylation of translation initiation factor eIF2α. However, mutation of eIF2α-phosphorylating GCN2 kinase did not affect BABA-induced immunity, but relieved BABA-induced growth repression. Hence, BABA-activated IBI1 controls plant immunity and growth via separate pathways. Our results open new opportunities to separate broad-spectrum disease resistance from the associated costs on plant growth.
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影响因子：
3.5
作者：
HOLUB, EB;BEYNON, LJ;CRUTE, IR
通讯作者：
CRUTE, IR
影响因子：
56.9
作者：
DELANEY, TP;UKNES, S;RYALS, J
通讯作者：
RYALS, J
影响因子：
14.8
作者：
Guo, Min;Schimmel, Paul
通讯作者：
Schimmel, Paul
DOI：
10.1073/pnas.011405198
发表时间：
2001-01-02
影响因子：
11.1
作者：
Frye, CA;Tang, DZ;Innes, RW
通讯作者：
Innes, RW
影响因子：
4.8
作者：
Ko, YG;Kim, EK;Kim, S
通讯作者：
Kim, S