Anxiety and amygdala connectivity during movie-watching.
Anxiety and amygdala connectivity during movie-watching.
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看电影时的焦虑和杏仁核连接。
DOI：
10.1016/j.neuropsychologia.2022.108194
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发表时间：
2022-05-03
期刊：
影响因子：
2.6
通讯作者：
Skipper JI
中科院分区：
文献类型：
--
作者：
Kirk PA;Robinson OJ;Skipper JI
啮齿动物和人类的研究表明，在威胁处理过程中，杏仁核-前额叶回路是存在的。一种可能性是，虽然杏仁核的活动是焦虑的核心特征（例如，对显著信息的检测）的基础，但前额皮质（即背内侧前额叶/前扣带皮层）控制了它的反应性。到目前为止，这已经建立在严格控制的范式（主要使用静态面部感知任务），但尚未扩展到更自然的环境。因此，使用“电影功能磁共振成像”——参与者观看生态丰富的电影刺激，而不是受约束的认知任务——我们试图在两个独立的样本中测试焦虑的个体差异是否与面部依赖的杏仁核-前额叶耦合程度相关。分析表明，作为焦虑的功能，面部依赖性上顶叶激活增加，言语依赖性听觉皮层激活减少。然而，无论是在刺激依赖性分析还是独立分析中，我们都未能找到焦虑依赖性连通性的证据。我们的研究结果表明，使用实验约束任务的工作可能无法在更生态有效的环境中复制，此外，强调了在原始环境之外测试神经影像学发现的普遍性的重要性。使用“电影功能磁共振成像”，我们测试了特质焦虑是否与面部依赖性杏仁核-前额叶耦合相关。我们观察到，作为焦虑的功能，上顶叶对面孔的激活和听觉皮层对言语的激活发生了改变。我们未能在刺激依赖或独立分析中找到焦虑依赖的杏仁核- dmpfc连接的证据。我们的研究结果强调了在原始环境之外测试神经影像学发现的普遍性的重要性。
Rodent and human studies have implicated an amygdala-prefrontal circuit during threat processing. One possibility is that while amygdala activity underlies core features of anxiety (e.g. detection of salient information), prefrontal cortices (i.e. dorsomedial prefrontal/anterior cingulate cortex) entrain its responsiveness. To date, this has been established in tightly controlled paradigms (predominantly using static face perception tasks) but has not been extended to more naturalistic settings. Consequently, using ‘movie fMRI’—in which participants watch ecologically-rich movie stimuli rather than constrained cognitive tasks—we sought to test whether individual differences in anxiety correlate with the degree of face-dependent amygdala-prefrontal coupling in two independent samples. Analyses suggested increased face-dependent superior parietal activation and decreased speech-dependent auditory cortex activation as a function of anxiety. However, we failed to find evidence for anxiety-dependent connectivity, neither in our stimulus-dependent or -independent analyses. Our findings suggest that work using experimentally constrained tasks may not replicate in more ecologically valid settings and, moreover, highlight the importance of testing the generalizability of neuroimaging findings outside of the original context. Using ‘movie fMRI’, we tested whether trait anxiety correlates with face-dependent amygdala-prefrontal coupling. We observed altered superior parietal activation to faces and auditory cortex activation to speech as a function of anxiety. We failed to find evidence for anxiety-dependent amygdala-dmPFC connectivity in stimulus-dependent or -independent analyses. Our findings highlight the importance of testing the generalizability of neuroimaging findings outside of the original context.
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