Hypogonadal men with type 2 diabetes mellitus have smaller bone size and lower bone turnover.
Hypogonadal men with type 2 diabetes mellitus have smaller bone size and lower bone turnover.
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DOI：
10.1016/j.bone.2017.03.039
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发表时间：
2017-06
期刊：
影响因子：
4.1
通讯作者：
Armamento-Villareal R
中科院分区：
文献类型：
--
作者：
Colleluori G;Aguirre L;Dorin R;Robbins D;Blevins D;Barnouin Y;Chen R;Qualls C;Villareal DT;Armamento-Villareal R
性腺功能减退症和2型糖尿病（T2 D）都与骨折风险增加有关。新出现的数据支持低睾酮对葡萄糖代谢的负面影响，然而，关于患有糖尿病的性腺功能减退男性的骨骼健康的信息很少。我们评估了患有T2 D的性腺功能减退男性的骨矿物质密度（BMD）、骨几何学和骨转换，并与未患糖尿病的性腺功能减退男性进行了比较。横断面研究，男性40-74岁，平均早晨睾酮（两次）< 300 ng/dl。用DXA测量骨密度（aBMD）;用外周定量计算机断层扫描测量骨密度（vBMD）和骨几何学;用ELISA法测量血清C-端肽（CTX）、骨钙素、硬化素和性激素结合球蛋白（SHBG）;用自动免疫分析法测量睾酮和25-羟维生素D（25 OHD）;用液相色谱/质谱法测量雌二醇。通过针对协变量调整的ANOVA比较各组。105名男性，49名患有糖尿病，56名没有糖尿病。糖尿病男性中38%胫骨的校正vBMD高于非糖尿病男性（857.3 ± 69.0 mg/cm 3 vs. 828.7 ± 96.7 mg/cm 3，p = 0.02）。骨内膜（43.9 ± 5.8 mm vs. 47.1 ± 7.8 mm，p = 0.04）和骨膜（78.4 ± 5.0 mm与81.3 ± 6.5 mm，p = 0.02）周长和总面积（491.0 ± 61.0 mm 2 vs. 527.7 ± 87.2 mm 2，p = 0.02），即使在调整协变量后，糖尿病男性中也较低。糖尿病男性中CTX（0.25 ± 0.14 ng/ml vs. 0.40 ± 0.19 ng/ml，p < 0.001）和骨钙素（4.8 ± 2.8 ng/ml vs. 6.8 ± 3.5 ng/ml，p = 0.006）较低;硬化素和25 OHD无差异。两组之间的循环性腺激素相当。在性腺功能减退的男性中，T2 D患者的BMD较高，骨几何学较差，骨转换相对受抑制。需要更大样本量的研究来验证我们的发现，性腺功能减退的糖尿病男性发生骨折的风险可能更大。
Both hypogonadism and type 2 diabetes mellitus (T2D) are associated with increased fracture risk. Emerging data support the negative effect of low testosterone on glucose metabolism, however, there is little information on the bone health of hypogonadal men with diabetes. We evaluated the bone mineral density (BMD), bone geometry and bone turnover of hypogonadal men with T2D compared to hypogonadal men without diabetes. Cross-sectional study, men 40–74 years old, with average morning testosterone (done twice) of < 300 ng/dl. Areal BMD (aBMD) was measured by DXA; volumetric BMD (vBMD) and bone geometry by peripheral-quantitative-computed-tomography; serum C-telopeptide (CTX), osteocalcin, sclerostin and sex hormone-binding globulin (SHBG) by ELISA, testosterone and 25-hydroxyvitamin D (25OHD) by automated immunoassay and estradiol by liquid-chromatography/mass-spectrometry. Groups were compared by ANOVA adjusted for covariates. One-hundred five men, 49 with and 56 without diabetes were enrolled. Adjusted vBMD at 38% tibia was higher in diabetic than non-diabetic men (857.3 ± 69.0 mg/cm3 vs. 828.7 ± 96.7 mg/cm3, p = 0.02). Endosteal (43.9 ± 5.8 mm vs. 47.1 ± 7.8 mm, p = 0.04) and periosteal (78.4 ± 5.0 mm vs. 81.3 ± 6.5 mm, p = 0.02) circumferences and total area (491.0 ± 61.0 mm2 vs. 527.7 ± 87.2 mm2, p = 0.02) at 38% tibia, were lower in diabetic men even after adjustments for covariates. CTX (0.25 ± 0.14 ng/ml vs. 0.40 ± 0.19 ng/ml, p < 0.001) and osteocalcin (4.8 ± 2.8 ng/ml vs. 6.8 ± 3.5 ng/ml, p = 0.006) were lower in diabetic men; there were no differences in sclerostin and 25OHD. Circulating gonadal hormones were comparable between the groups. Among hypogonadal men, those with T2D have higher BMD, poorer bone geometry and relatively suppressed bone turnover. Studies with larger sample size are needed to verify our findings and possible even greater risk for fractures among hypogonadal diabetic men.
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影响因子：
5.8
作者：
Furst, Jessica R.;Bandeira, Leonardo C.;Rubin, Mishaela R.
通讯作者：
Rubin, Mishaela R.
DOI：
10.1016/j.ecl.2013.09.004
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2014-03-01
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影响因子：
16.2
作者：
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通讯作者：
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影响因子：
6.2
作者：
Napoli, N;Villareal, DT;Armamento-Villareal, R
通讯作者：
Armamento-Villareal, R