Concomitant high expression of ERα36, EGFR and HER2 is associated with aggressive behaviors of papillary thyroid carcinomas.
Concomitant high expression of ERα36, EGFR and HER2 is associated with aggressive behaviors of papillary thyroid carcinomas.
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DOI：
10.1038/s41598-017-12478-1
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发表时间：
2017-09-25
影响因子：
4.6
通讯作者：
Liu ZM
中科院分区：
文献类型：
--
作者：
Dai YJ;Qiu YB;Jiang R;Xu M;Zhao L;Chen GG;Liu ZM
通过实时RT-PCR和免疫组化染色检测甲状腺乳头状癌（PTC）中ERα、ERβ、PR、ERα36、EGFR和HER2 mRNA和蛋白的表达。从正常甲状腺组织到结节性增生组织（P<0.05）和PTC组织（P<0.05），ERα、PR mRNA和蛋白表达量逐渐升高，ERβmRNA和蛋白表达量逐渐降低。然而，与正常甲状腺组织（P<0.001）和结节性增生组织（P<0.001）相比，PTC中ERα36、EGFR和HER2 mRNA和蛋白表达量仅显着升高。 PTC中ERα、ERβ和PR之间以及ERα36、EGFR和HER2蛋白表达之间存在一定的相关性。 ERα、ERβ和PR之间，ERα与PR之间呈显着正相关，ERα与ERβ之间、PR与ERβ蛋白表达之间呈显着负相关。至于ERα36、EGFR和HER2，PTC中ERα36、EGFR和HER2蛋白表达量呈显着正相关。 ERα36、EGFR 和 HER2 的同时高表达与 PTC 中的侵袭性行为密切相关，包括甲状腺外扩展 (ETE)、淋巴结转移 (LNM) 和高 TNM 分期 (P<0.001)。
ERα, ERβ, PR, ERα36, EGFR and HER2 mRNA and protein expression in papillary thyroid carcinoma (PTC) were examined by real time RT-PCR and immunohistochemical staining. The mRNA and protein expression of ERα and PR were gradually increased and those of ERβ were gradually decreased from normal thyroid tissues to nodular hyperplasias (P < 0.05) and to PTCs (P < 0.05). However, the mRNA and protein expression of ERα36, EGFR and HER2 were only significantly increased in PTCs when compared with those in normal thyroid tissues (P < 0.001) and nodular hyperplasias (P < 0.001). There was some correlation between ERα, ERβ and PR, and between ERα36, EGFR and HER2 protein expression in PTCs. As for ERα, ERβ and PR, there was a significant positive correlation between ERα and PR, and a significant negative correlation between ERα and ERβ and between PR and ERβ protein expression. As for ERα36, EGFR and HER2, there was a significant positive correlation between ERα36, EGFR and HER2 protein expression in PTCs. Concomitant high expression of ERα36, EGFR and HER2 was strongly associated with aggressive behaviors including extrathyroidal extension (ETE), lymph node metastasis (LNM) and high TNM stage in PTCs (P < 0.001).
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