Zaire ebolavirus surveillance near the Bikoro region of the Democratic Republic of the Congo during the 2018 outbreak reveals presence of seropositive bats.
Zaire ebolavirus surveillance near the Bikoro region of the Democratic Republic of the Congo during the 2018 outbreak reveals presence of seropositive bats.
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DOI：
10.1371/journal.pntd.0010504
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发表时间：
2022-06
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
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作者：
2018年5月8日，宣布埃博拉病毒病（EVD）爆发，起源于刚果民主共和国（DRC）与邻国刚果共和国（ROC）边境附近的比科罗地区。刚果民主共和国和居住在沿着刚果河的中华民国社区之间经常发生贸易和移民。2018年6月，部署了一个现场小组，以确定扎伊尔埃博拉病毒（埃博拉病毒（EBOV））是否同时在Bikoro EVD爆发附近的ROC人-动物界面的当地蝙蝠中传播。样本采集自中华民国Cuvette和Likouala省的蝙蝠，与刚果民主共和国赤道省接壤，首次发现Bikoro EVD爆发。通过靶向定量逆转录-聚合酶链反应或家族水平一致聚合酶链反应，在蝙蝠来源的样本中未检测到EBOV基因组物质;然而，血清学数据表明该地区蝙蝠最近暴露于EBOV。我们收集了144蝙蝠在比色皿部门与6.9%的血清阳性对EBOV糖蛋白和14.3%的血清阳性收集的血清从27果蝠和一个Molossinae在利夸拉部门。我们的结论是，需要在人-动物界面的丝状病毒纵向采样方面进行积极投资，再加上生态调查，以确定EBOV野生动物宿主。扎伊尔埃博拉病毒（埃博拉病毒，（EBOV））于40多年前首次被发现，是埃博拉病毒病（EVD）的病原体，与病毒性出血热相关。EBOV被认为通过与野生动物接触传播给人类。虽然蝙蝠被怀疑是自然界中维持EBOV的宿主，但目前还不知道哪些蝙蝠物种是宿主。确定在自然界中维持EBOV的野生动物物种将有助于制定战略，以减轻EBOV从野生动物传播给人类的风险。在这份手稿中，我们描述了监测工作的结果，以检测埃博拉病毒在野生动物附近的同期爆发的EBOV疾病在人类。我们通过血清学技术在EVD爆发地点附近的蝙蝠中检测到最近EBOV感染的证据，但我们没有发现蝙蝠中EBOV活跃感染的证据。这些数据支持在埃博拉病毒流行地区对野生动物进行更积极主动监测的必要性。
On the 8th of May, 2018, an outbreak of Ebola virus disease (EVD) was declared, originating in the Bikoro region of the Democratic Republic of the Congo (DRC) near the border with neighboring Republic of the Congo (ROC). Frequent trade and migration occur between DRC and ROC-based communities residing along the Congo River. In June 2018, a field team was deployed to determine whether Zaire ebolavirus (Ebola virus (EBOV)) was contemporaneously circulating in local bats at the human-animal interface in ROC near the Bikoro EVD outbreak. Samples were collected from bats in the Cuvette and Likouala departments, ROC, bordering the Équateur Province in DRC where the Bikoro EVD outbreak was first detected. EBOV genomic material was not detected in bat-derived samples by targeted quantitative reverse transcription-polymerase chain reaction or by family-level consensus polymerase chain reaction; however, serological data suggests recent exposure to EBOV in bats in the region. We collected serum from 144 bats in the Cuvette department with 6.9% seropositivity against the EBOV glycoprotein and 14.3% seropositivity for serum collected from 27 fruit bats and one Molossinae in the Likouala department. We conclude that proactive investment in longitudinal sampling for filoviruses at the human-animal interface, coupled with ecological investigations are needed to identify EBOV wildlife reservoirs. Zaire ebolavirus (Ebola virus, (EBOV)), first characterized more than 40 years ago, is a causative agent of Ebola virus disease (EVD) which is associated with viral hemorrhagic fever. EBOV is thought to be transmitted to humans through contact with wildlife. Though bats are suspected to be the hosts that maintain EBOV in nature, it is currently not known which bat species serve as the reservoir. Identifying the wildlife species that maintain EBOV in nature would facilitate the development of strategies to mitigate the risk of EBOV transmission to humans from wildlife. In this manuscript, we describe the results of surveillance efforts to detect Ebola virus in wildlife near a contemporaneous outbreak of EBOV disease in humans. We detected evidence of recent EBOV infection in bats near the location of the EVD outbreak through serological techniques, but we did not find evidence of active EBOV infection in bats. These data support the need for more proactive surveillance in wildlife in EBOV endemic regions.
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影响因子：
2.5
作者：
Leendertz SA;Gogarten JF;Düx A;Calvignac-Spencer S;Leendertz FH
通讯作者：
Leendertz FH
影响因子：
2
作者：
Bouchard, S
通讯作者：
Bouchard, S
影响因子：
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作者：
Hranac, C. Reed;Marshall, Jonathan C.;Hayman, David T. S.
通讯作者：
Hayman, David T. S.
影响因子：
11.8
作者：
Gryseels, Sophie;Mbala-Kingebeni, Placide;Ahuka-Mundeke, Steve
通讯作者：
Ahuka-Mundeke, Steve
从2018年起，调查了埃博拉病毒疾病爆发期间蝙蝠病毒疾病爆发期间的埃博拉病毒的循环。
DOI：
10.3390/pathogens10050557
发表时间：
2021-05-04
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Lacroix A;Mbala Kingebeni P;Ndimbo Kumugo SP;Lempu G;Butel C;Serrano L;Vidal N;Thaurignac G;Esteban A;Mukadi Bamuleka D;Likofata J;Delaporte E;Muyembe Tamfum JJ;Ayouba A;Peeters M;Ahuka Mundeke S
通讯作者：
Ahuka Mundeke S