Rapid and sensitive determination of doxorubicin in human whole blood by vertically-ordered mesoporous silica film modified electrochemically pretreated glassy carbon electrodes.
Rapid and sensitive determination of doxorubicin in human whole blood by vertically-ordered mesoporous silica film modified electrochemically pretreated glassy carbon electrodes.
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垂直有序介孔二氧化硅膜修饰电化学预处理玻碳电极快速灵敏测定人全血中的阿霉素
DOI：
10.1039/d0ra10000e
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发表时间：
2021-02-23
期刊：
影响因子：
3.9
通讯作者：
Yan F
中科院分区：
文献类型：
--
作者：
Wang M;Lin J;Gong J;Ma M;Tang H;Liu J;Yan F
直接准确地检测未经处理的人全血中的阿霉素（DOX）在医学诊断和监测中至关重要。在这项工作中，我们证明了利用电化学预处理的玻碳电极（p-GCE）改性的垂直有序介孔二氧化硅膜（VMSF）的快速和灵敏的电化学检测DOX。电化学预处理过程是一种简单，成本效益和环境友好的方法，用于改善界面催化性能，并将含氧基团引入GCE表面，这可能适用于稳定生长VMSF，而无需任何粘合剂层，同时保持底层电极活性。利用p-GCE的高灵敏度电极基底和VMSF的静电预富集效应，该传感器具有较高的灵敏度（23.94 μA μM−1）、较低的检测限（0.2 nM）和较宽的线性范围（0.5 nM ~ 23 μM）。此外，由于VMSF具有良好的抗污染和抗干扰能力，无需复杂的样品前处理，实现了直接可靠的人全血中DOX的电化学检测。
Direct and accurate detection of doxorubicin (DOX) in unprocessed human whole blood is of vital importance in medical diagnosis and monitoring. In this work, we demonstrate the utilization of electrochemically pretreated glassy carbon electrodes (p-GCE) modified with vertically-ordered mesoporous silica films (VMSF) for rapid and sensitive electrochemical detection of DOX. The electrochemically pretreated process is a simple, cost-effective and environmentally friendly approach for improving interface catalytic properties and introducing oxygen-containing groups into the GCE surface, which could be suitable for stably growing VMSF without any adhesive layer simultaneously retaining the underlying electrode activity. Benefiting from the highly sensitive electrode substrate of p-GCE and electrostatic preconcentration effect of VMSF, the present VMSF/p-GCE sensor was able to determine DOX with an ultrahigh sensitivity (23.94 μA μM−1) and a relatively low limit of detection (0.2 nM) and a rather wide linear range (0.5 nM to 23 μM). Furthermore, direct and reliable electrochemical detection of DOX in human whole blood without complicated sample pretreatments was achieved owing to the excellent anti-fouling and anti-interference ability of VMSF.
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