Evaluating testosterone as a phenotypic integrator: From tissues to individuals to species
Evaluating testosterone as a phenotypic integrator: From tissues to individuals to species
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评估睾酮作为表型整合剂：从组织到个体到物种
DOI：
10.1016/j.mce.2019.110531
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发表时间：
2019
影响因子：
4.1
通讯作者：
Rosvall, K.A.
中科院分区：
文献类型：
--
作者：
Lipshutz, S.E.;George, E.M.;Bentz, A.B.;Rosvall, K.A.
要点睾酮(T)被认为整合了一起工作良好的表型。然而，目前还不清楚这种整合是如何在有机体内产生的。T、受体和酶的表达在组织中并不总是共同变化的。内分泌整合的模式因繁殖阶段、性别和种群而异。种群内有限的整合可以促进Traits的独立进化。荷尔蒙有可能带来快速的表型变化；然而，经过数百万年的进化，它们是高度保守的。在这里，我们研究激素介导的表型的进化，以及通过内分泌系统的许多组成部分的独立或整合实现调节的程度。我们的重点是性类固醇睾酮(T)，其同源受体(雄激素受体)和相关的内分泌成分。我们对表型整合的潜在机制提出了预测，包括组织内和组织间以及沿HPG轴对T的协调敏感性。然后，我们用野生鸟类的案例研究来评估这些预测，询问与雄激素信号相关的基因表达是否在个体之间自然地协同变化，从而促进表型整合。最后，我们回顾了整合和独立的机制如何随着发展或进化时间的变化而变化，我们发现对整合的支持有限。
HighlightsTestosterone (T) is thought to integrate phenotypes that work well together.However, it is not clear how such integration is generated within the organism.T, receptors, and enzyme expression do not consistently co-vary across tissues.Patterns of endocrine integration vary across breeding stages, sex, and populations.Limited integration within populations could facilitate independent evolution of traits.Hormones have the potential to bring about rapid phenotypic change; however, they are highly conserved over millions of years of evolution. Here, we examine the evolution of hormone-mediated phenotypes, and the extent to which regulation is achieved via independence or integration of the many components of endocrine systems. We focus on the sex steroid testosterone (T), its cognate receptor (androgen receptor) and related endocrine components. We pose predictions about the mechanisms underlying phenotypic integration, including coordinated sensitivity to T within and among tissues and along the HPG axis. We then assess these predictions with case studies from wild birds, asking whether gene expression related to androgenic signaling naturally co-varies among individuals in ways that would promote phenotypic integration. Finally, we review how mechanisms of integration and independence vary over developmental or evolutionary time, and we find limited support for integration.
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DOI：
10.1093/acprof:oso/9780199568765.003.0026
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