Phenotypic integration mediated by hormones: associations among digit ratios, body size and testosterone during tadpole development.
Phenotypic integration mediated by hormones: associations among digit ratios, body size and testosterone during tadpole development.
复制标题
DOI：
10.1186/s12862-017-1021-0
复制
发表时间：
2017-08-02
影响因子：
3.4
通讯作者：
Kohlsdorf T
中科院分区：
文献类型：
--
作者：
Lofeu L;Brandt R;Kohlsdorf T
发育关联通常解释表型整合。个体发育过程的激素调节促进了类固醇介导的性二型性状表型整合的预测，这一说法被经典的二型预测因子（例如体型）和明显缺乏性别特异性功能的性状（例如第二趾和第四趾的长度之比- 2D：4D）之间的关联所否定。雌性偏向的2D：4D的发育基础已经确定，但这些仍然不清楚的类群呈现雄性偏向的2D：4D（例如无尾类）。在这里，我们提出了两个替代假设来研究雄性偏见的2D：4D的进化与使用细趾蛙的性二形体型相关：I）“性别特异性手指反应的假设”-手指IV将对睾酮产生反应，但表现出相反的反应方向在雌性偏见的2D：4D谱系中观察到的反应，因此男性的手指IV变短; II）“双态指同一性假说”-指II将是双态指。本研究以细趾蛙为研究对象，建立了以下数据库：（1）两种自然种群的细趾蛙成虫和（2）经睾酮处理的细趾蛙成虫。后变质期的梭状细胞。所研究的性状在L. fuscus）; L. podalinus表现出雄性偏向的2D：4D。当存在时，2D：4D二型性是男性偏见，并与二型体大小;性别差异居住在第二，而不是第四，证实了我们的“身份的二型数字的假设”。发育类固醇的作用得到验证：睾酮处理的L。fuscus青蛙较小，表现出雄性化的2D：4D，第二趾是对睾酮有反应的趾。我们提出了一个模型，在2D：4D的性二态性的演变首先起源于出现，在一个给定的数字，增加组织对类固醇的敏感性。与其他性二态性状的表型整合将通过发育过程中的多性状激素效应发生。这种表型整合的过程似乎在其起源中与适合度无关，并可能解释性二型性状中类固醇介导的整合的几个案例。本文的在线版本（doi：10.1186/s12862-017-1021-0）包含补充材料，可供授权用户使用。
Developmental associations often explain phenotypic integration. The intersected hormonal regulation of ontogenetic processes fosters predictions of steroid-mediated phenotypic integration among sexually dimorphic traits, a statement defied by associations between classical dimorphism predictors (e.g. body size) and traits that apparently lack sex-specific functions (e.g. ratios between the lengths of Digits II and IV - 2D:4D). Developmental bases of female-biased 2D:4D have been identified, but these remain unclear for taxa presenting male-biased 2D:4D (e.g. anura). Here we propose two alternative hypotheses to investigate evolution of male-biased 2D:4D associated with sexually dimorphic body size using Leptodactylus frogs: I)‘hypothesis of sex-specific digit responses’ - Digit IV would be reactive to testosterone but exhibit responses in the opposite direction of those observed in female-biased 2D:4D lineages, so that Digit IV turns shorter in males; II) ‘hypothesis of identity of the dimorphic digit’- Digit II would be the dimorphic digit. We compiled the following databases using Leptodactylus frogs: 1) adults of two species from natural populations and 2) testosterone-treated L. fuscus at post-metamorphic stage. Studied traits seem monomorphic in L. fuscus; L. podicipinus exhibits male-biased 2D:4D. When present, 2D:4D dimorphism was male-biased and associated with dimorphic body size; sex differences resided on Digit II instead of IV, corroborating our ‘hypothesis of identity of the dimorphic digit’. Developmental steroid roles were validated: testosterone-treated L. fuscus frogs were smaller and exhibited masculinized 2D:4D, and Digit II was the digit that responded to testosterone. We propose a model where evolution of sexual dimorphism in 2D:4D first originates from the advent, in a given digit, of increased tissue sensitivity to steroids. Phenotypic integration with other sexually dimorphic traits would then occur through multi-trait hormonal effects during development. Such process of phenotypic integration seems fitness-independent in its origin and might explain several cases of steroid-mediated integration among sexually dimorphic traits. The online version of this article (doi:10.1186/s12862-017-1021-0) contains supplementary material, which is available to authorized users.
登录
查看更多内容
DOI：
10.1098/rspb.2013.1532
发表时间：
2013-10-07
影响因子：
4.7
作者：
Auger, Jacques;Le Denmat, Dominique;Eustache, Florence
通讯作者：
Eustache, Florence
影响因子：
2.6
作者：
Cox, Robert M.;McGlothlin, Joel W.;Bonier, Frances
通讯作者：
Bonier, Frances
影响因子：
2.5
作者：
Bailey, AA;Wahlsten, D;Hurd, PL
通讯作者：
Hurd, PL
DOI：
10.1002/ar.22411
发表时间：
2012-04-01
影响因子：
2
作者：
Direnzo, Graziella Vittoria;Stynoski, Jennifer Lynn
通讯作者：
Stynoski, Jennifer Lynn
影响因子：
3.8
作者：
Galis, Frietson;Ten Broek, Clara M. A.;Van Dongen, Stefan;Wijnaendts, Liliane C. D.
通讯作者：
Wijnaendts, Liliane C. D.