Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.
Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.
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DOI：
10.1038/s41467-022-28057-6
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发表时间：
2022-02-08
影响因子：
16.6
通讯作者：
Fortin NJ
中科院分区：
文献类型：
--
作者：
Shahbaba B;Li L;Agostinelli F;Saraf M;Cooper KW;Haghverdian D;Elias GA;Baldi P;Fortin NJ
海马体对我们的经历的时间组织至关重要。虽然这种基本的能力是保守的跨模式和物种，其潜在的神经元机制仍然不清楚。在这里，我们记录了海马体的活动，因为大鼠记住了一系列在几秒钟内展开的非空间事件，就像人类的日常生活一样。然后，我们开发了统计机器学习方法来分析整体活动，并发现了顺序组织和编码的形式对顺序记忆判断很重要。具体来说，我们发现，海马合奏提供了显着的时间编码整个非空间事件序列，区分不同类型的任务关键信息顺序内的事件，并表现出θ相关的事件之间的顺序关系的再激活。我们还表明，非空间事件的表征是按顺序组织在个别θ周期和进动跨越连续的周期。这些发现表明海马网络的基本功能是编码，保存和预测经验的顺序。海马体的活动是如何支持我们经历的时间组织的，目前还不清楚。在本文中，作者记录了大鼠执行气味序列任务，并表明海马系综代表了非空间事件在不同时间尺度上的顺序关系。
The hippocampus is critical to the temporal organization of our experiences. Although this fundamental capacity is conserved across modalities and species, its underlying neuronal mechanisms remain unclear. Here we recorded hippocampal activity as rats remembered an extended sequence of nonspatial events unfolding over several seconds, as in daily life episodes in humans. We then developed statistical machine learning methods to analyze the ensemble activity and discovered forms of sequential organization and coding important for order memory judgments. Specifically, we found that hippocampal ensembles provide significant temporal coding throughout nonspatial event sequences, differentiate distinct types of task-critical information sequentially within events, and exhibit theta-associated reactivation of the sequential relationships among events. We also demonstrate that nonspatial event representations are sequentially organized within individual theta cycles and precess across successive cycles. These findings suggest a fundamental function of the hippocampal network is to encode, preserve, and predict the sequential order of experiences. It remains unclear how hippocampal activity supports the temporal organization of our experiences. In this paper, the authors recorded from rats performing an odor sequence task and show that hippocampal ensembles represent the sequential relations among nonspatial events at different timescales.
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DOI：
10.1016/s0163-1047(05)80065-2
发表时间：
1994-03-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
CHIBA, AA;KESNER, RP;REYNOLDS, AM
通讯作者：
REYNOLDS, AM
影响因子：
64.5
作者：
Kay, Kenneth;Chung, Jason E.;Frank, Loren M.
通讯作者：
Frank, Loren M.
影响因子：
3
作者：
Kempter, Richard;Leibold, Christian;Schmidt, Robert
通讯作者：
Schmidt, Robert
影响因子：
1.8
作者：
Howard, MW;Kahana, MJ
通讯作者：
Kahana, MJ
影响因子：
3.5
作者：
Foster, David J.;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.