The effect of acute exercise on pre-prandial ghrelin levels in healthy adults: A systematic review and meta-analysis.
The effect of acute exercise on pre-prandial ghrelin levels in healthy adults: A systematic review and meta-analysis.
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DOI：
10.1016/j.peptides.2021.170625
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发表时间：
2021-11
期刊：
影响因子：
3
通讯作者：
Allen, Jason D.
中科院分区：
文献类型：
--
作者：
Anderson, Kara C.;Zieff, Gabriel;Paterson, Craig;Stoner, Lee;Weltman, Arthur;Allen, Jason D.
胃饥饿素是一种具有多种生理作用的肠道激素，包括调节能量平衡、胰岛素敏感性、血管健康和身体成分。酰化（AG）和去酰化（DAG）的胃饥饿素分别约占血浆胃饥饿素（TG）总量的22%和78%。TG浓度和AG/DAG比值的改变可能与能量失衡和胰岛素抵抗状态有关（如代谢综合征或2型糖尿病）。运动是一种治疗选择，可以潜在地优化胃促生长素水平。了解运动的精确强度和剂量以优化胃饥饿素水平可能导致有针对性的干预，以恢复肥胖和其他临床疾病的代谢调节。对急性运动对健康成人餐前TG、AG和DAG水平的影响进行系统回顾和荟萃分析，并确定样本人口统计学或运动剂量是否能调节这种影响。检索了截至2020年8月发表的文章的电子数据库（PubMed, Medline, SPORTDiscus， Web of Science和谷歌Scholar）。以下是先验确定的物品纳入标准：(i)该研究是一项随机对照试验（RCT），（ii）运动是急性回合，（iii）干预组/条件的运动回合是结构化的，（iv）对照组/条件不接受运动，(v)参与者是18岁或以上的成年人，（vi）通过血液采集胃饥饿素，（vii）至少有一个胃饥饿素的基线测量和一个运动后测量。（viii）至少有3个时间点在参与者禁食时测量胃饥饿素，以便计算餐前曲线下总面积（AUCtotal）， （ix）参与者健康，无明显疾病，(x)在没有任何环境操纵的情况下进行干预。使用限制最大似然估计（restricted maximum likelihood estimation）计算95%置信区间的标准化平均差（SMD），以确定总体汇总效应是否受到以下因素的影响：性别、胃饥饿素形式、胃饥饿素分析方法、年龄、体重指数、体脂率、健身、运动强度、运动持续时间、能量消耗和AUCtotal数据长度。该分析纳入了24项研究，包括52项试验，n = 504项（年龄27.0（8.8）岁，BMI 24.7 (2.7) kg/m2），并测量了AG （n = 38项试验）、DAG （n = 7）和TG （n = 7）。整体模型表明，与对照组（不运动）相比，运动降低了胃饥饿素水平；（SMD= - 0.44, p < 0.001），运动强度与胃饥饿素水平呈负相关（回归系数（ß）= - 0.016, p = 0.04）。胃饥饿素形式差异无统计学意义（p = 0.18）。急性运动显著降低血浆胃饥饿素水平，高强度运动与更大的胃饥饿素抑制相关。大多数研究采用中等强度运动并测量AG， DAG数据有限。这种运动剂量可能对代谢失调和能量不平衡的个体具有临床意义，可以作为优化AG水平的治疗方法。在临床人群中，需要更多的工作来比较中等强度和高强度运动和胃饥饿素反应。
Ghrelin is a gut hormone with numerous physiological effects, including the regulation of energy balance, insulin sensitivity, vascular health, and body composition. Acylated (AG) and des-acylated (DAG) ghrelin constitute approximately 22 % and 78 % of total plasma ghrelin (TG), respectively. Alterations in the TG concentration and the AG/DAG ratio may be implicated in conditions involving energy imbalances and insulin resistant states (e.g., metabolic syndrome or Type 2 diabetes mellitus). Exercise is a therapeutic option that can potentially optimize ghrelin levels. Understanding the precise intensity and dose of exercise to optimize ghrelin levels may lead to targeted interventions to restore metabolic regulation in obesity and other clinical conditions. To perform a systematic review and meta-analysis on the effects of acute exercise on pre-prandial levels of TG, AG, and DAG in healthy adults and to determine if sample demographics or exercise doses moderate such effects. Electronic databases (PubMed, Medline, SPORTDiscus, Web of Science, and Google Scholar) were searched with articles published through August 2020. The following criteria was determined a priori for article inclusion: (i) the study was a randomized controlled trial (RCT),(ii) exercise was an acute bout, (iii) the exercise bout for the intervention group(s)/condition was structured, (iv) the control group/condition received no exercise, (v) participants were adults age 18 or older, (vi) ghrelin was sampled through blood, (vii) there was at least one baseline measure and one post-exercise measure of ghrelin, (viii) there were at least 3 timepoints where ghrelin was measured while participants were fasted to allow for pre-prandial total area-under-the-curve (AUCtotal) calculation, (ix) participants were healthy with no overt disease, (x) interventions were carried out without any environmental manipulations. Standardized mean difference (SMD) with 95 % confidence intervals were calculated using the restricted maximum likelihood estimation Moderator analyses to determine whether the overall pooled effect was influenced by: sex, ghrelin form, method of ghrelin analysis, age, body mass index, body fat percentage, fitness, intensity of exercise bout, duration of exercise bout, energy expenditure, and length of AUCtotal data. The analysis included 24 studies that consisted of 52 trials, n = 504 (age 27.0 (8.8) years, BMI 24.7 (2.7) kg/m2) and measured AG (n = 38 trials), DAG (n = 7), and TG (n = 7). The overall model indicated that exercise lowered ghrelin levels compared to control (no exercise); (SMD=−0.44, p < 0.001), and exercise intensity exhibited an inverse relationship with ghrelin levels (regression coefficient (ß)=−0.016, p = 0.04). There was no significant difference by ghrelin form (p = 0.18). Acute exercise significantly lowers plasma ghrelin levels, with higher intensity exercise associated with greater ghrelin suppression. The majority of studies applied a moderate intensity exercise bout and measured AG, with limited data on DAG. This exercise dose may be clinically significant in individuals with metabolic dysregulation and energy imbalance as a therapy to optimize AG levels. More work is needed to compare moderate and high intensity exercise and the ghrelin response in clinical populations.
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影响因子：
5.6
作者：
Colldén G;Tschöp MH;Müller TD
通讯作者：
Müller TD
DOI：
10.1249/mss.0000000000000793
发表时间：
2016-03-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Alajmi, Nawal;Deighton, Kevin;Stensel, David J.
通讯作者：
Stensel, David J.
影响因子：
15.1
作者：
Bishop, Nicolette C.;Hayashida, Harumi;Stensel, David J.
通讯作者：
Stensel, David J.
影响因子：
3.3
作者：
Broom, D. R.;Stensel, D. J.;Miyashita, M.
通讯作者：
Miyashita, M.
DOI：
10.1152/ajpregu.90706.2008
发表时间：
2009-01-01
影响因子：
2.8
作者：
Broom, David R.;Batterham, Rachel L.;Stensel, David J.
通讯作者：
Stensel, David J.