Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model.
Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model.
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DOI：
10.1002/mnfr.201300230
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发表时间：
2013-12
影响因子：
5.2
通讯作者：
Pasinetti, Giulio M.
中科院分区：
文献类型：
--
作者：
Wang, Jun;Tang, Cheuk;Ferruzzi, Mario G.;Gong, Bing;Song, Brian J.;Janle, Elsa M.;Chen, Tzu-Ying;Cooper, Bruce;Varghese, Merina;Cheng, Alice;Freire, Daniel;Bilski, Amanda;Roman, Jessica;Tuyen Nguyen;Ho, Lap;Talcott, Stephen T.;Simon, James E.;Wu, Qingli;Pasinetti, Giulio M.
代谢综合征已成为一种流行病，给卫生系统带来了巨大的负担。患有代谢综合征的人更有可能经历认知能力下降。随着肥胖和久坐不动的生活方式越来越普遍，制定早期预防战略至关重要。在这项研究中，我们探讨了葡萄籽提取物，协和紫葡萄汁提取物和白藜芦醇组成的组合多酚制剂，称为标准化葡萄多酚制剂（SGP），对外周以及代谢综合征引起的脑功能障碍的潜在有益影响。我们发现膳食脂肪含量对SGP中主要多酚的吸收和代谢产物的影响很小。利用饮食诱导的代谢综合征（DIM）动物模型，我们发现DIM小鼠的脑功能连接和突触可塑性受损。SGP治疗不仅可预防外周代谢异常，而且可改善脑突触可塑性。我们的研究表明，SGP由多种生物可利用和生物活性成分组成，靶向广泛的代谢综合征相关的病理特征，提供更大的全球保护，防止外周和中枢神经系统功能障碍，并可能被开发为改善大脑连接和突触可塑性的新型预防/治疗，这对学习和记忆很重要。
Metabolic syndrome has become an epidemic and poses tremendous burden on the health system. People with metabolic syndrome are more likely to experience cognitive decline. As obesity and sedentary lifestyles become more common, the development of early prevention strategies are critical. In this study, we explore the potential beneficial effects of a combinatory polyphenol preparation composed of grape seed extract, Concord purple grape juice extract and resveratrol, referred to as Standardized Grape Polyphenol Preparation (SGP), on peripheral as well as brain dysfunction induced by metabolic syndrome. We found dietary fat content had minimal effects on absorption and metabolites of major polyphenols derived from SGP. Using a diet-induced animal model of metabolic syndrome (DIM), we found that brain functional connectivity and synaptic plasticity are compromised in the DIM mice. Treatment with SGP not only prevented peripheral metabolic abnormality but also improved brain synaptic plasticity. Our study demonstrated that SGP comprised of multiple bioavailable and bioactive components targeting a wide range of metabolic syndrome-related pathological features provides greater global protection against peripheral and central nervous system dysfunctions and can be potentially developed as novel prevention/treatment for improving brain connectivity and synaptic plasticity important for learning and memory.
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影响因子：
2.9
作者：
HAIER, RJ;SIEGEL, BV;BUCHSBAUM, MS
通讯作者：
BUCHSBAUM, MS
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
6.1
作者：
Al-Awwadi, NA;Bornet, A;Teissedre, PL
通讯作者：
Teissedre, PL
影响因子：
5.6
作者：
Montagut, Gemma;Blade, Cinta;Ardevol, Anna
通讯作者：
Ardevol, Anna
影响因子：
3.3
作者：
Li, XL;Aou, S;Hori, T
通讯作者：
Hori, T