Triggering of stroke by ambient temperature variation: a case-crossover study in Maputo, Mozambique.
Triggering of stroke by ambient temperature variation: a case-crossover study in Maputo, Mozambique.
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DOI：
10.1016/j.clineuro.2014.12.002
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发表时间：
2015-02
影响因子：
1.9
通讯作者：
Lunet N
中科院分区：
文献类型：
--
作者：
Gomes J;Damasceno A;Carrilho C;Lobo V;Lopes H;Madede T;Pravinrai P;Silva-Matos C;Diogo D;Azevedo A;Lunet N
环境温度作为中风触发因素的影响可能因中风类型而异，并取决于影响这一结果风险的非瞬时暴露。我们的目的是量化环境温度变化与中风之间的关系，根据事件的临床特征，以及中风的其他危险因素。我们基于莫桑比克首都马普托因新发生的缺血性和出血性中风事件而入院的1年登记进行了一项病例交叉研究（N = 593）。病例期定义为卒中事件发生前7天，与两个对照期（卒中事件发生前14-21天和21-28天）进行比较。我们使用条件逻辑回归计算湿度和降水调整后的优势比（OR）和95%置信区间（95% ci）。仅在首次事件中观察到前一周连续两天最低体温下降超过2.4°C与卒中发生之间的关联（OR = 1.43, 95%CI: 1.15-1.76）。出血性卒中（OR = 1.50, 95%CI: 1.07-2.09）和未暴露于吸烟、高血清胆固醇或房颤等危险因素的受试者之间存在更强且具有统计学意义的关联。根据事件发生后28天患者的生命状态，温度的影响没有差异。第一次中风，尤其是出血性中风，是由前一周连续几天的最低温度下降引起的。
The effect of ambient temperature as a stroke trigger is likely to differ by type of stroke and to depend on non-transient exposures that influence the risk of this outcome. We aimed to quantify the association between ambient temperature variation and stroke, according to clinical characteristics of the events, and other risk factors for stroke. We conducted a case-crossover study based on a 1-year registry of the hospital admissions due to newly occurring ischemic and hemorrhagic stroke events in Maputo, Mozambique's capital city (N = 593). The case-period was defined as the 7 days before the stroke event, which was compared to two control periods (14–21 days and 21–28 days before the event). We computed humidity- and precipitation-adjusted odds ratios (OR) and 95% confidence intervals (95%CI) using conditional logistic regression. An association between minimum temperature declines higher than 2.4 °C in any two consecutive days in the previous week and the occurrence of stroke was observed only for first events (OR = 1.43, 95%CI: 1.15–1.76). Stronger and statistically significant associations were observed for hemorrhagic stroke (OR = 1.50, 95%CI: 1.07–2.09) and among subjects not exposed to risk factors, including smoking, high serum cholesterol or atrial fibrillation. No differences in the effect of temperature were found according to the patients’ vital status 28 days after the event. First stroke events, especially of the hemorrhagic type, were triggered by declines in the minimum temperature between consecutive days of the preceding week.
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影响因子：
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DOI：
10.1016/j.jstrokecerebrovasdis.2013.02.012
发表时间：
2014-02
影响因子：
2.5
作者：
Gomes, Joana;Damasceno, Albertino;Carrilho, Carla;Lobo, Vitoria;Lopes, Helder;Madede, Tavares;Pravinrai, Pius;Silva-Matos, Carla;Diogo, Domingos;Azevedo, Ana;Lunet, Nuno
通讯作者：
Lunet, Nuno