Resistant hypertension-defining the scope of the problem.

Resistant hypertension-defining the scope of the problem.
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DOI:
10.1016/j.pcad.2019.12.006
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发表时间:
2020-01
影响因子:
9.1
通讯作者:
Vongpatanasin W
Vongpatanasin W
中科院分区:
医学2区
文献类型:
--
作者:
Chia R;Pandey A;Vongpatanasin W

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美国心脏协会更新的科学声明将顽固性高血压(HTN; RH)定义为不受控制的血压(BP)≥ 130/80 mmHg,尽管同时使用3种抗HTN药物类别,包括钙通道阻滞剂、肾素-血管紧张素系统阻滞剂和噻嗪类利尿剂,优选氯噻酮。使用更新的BP标准,发现美国的RH患病率在治疗人群中适度增加约3-4%。观察性研究的荟萃分析表明,来自白色被毛HTN或药物不依从性的假RH与真正的RH一样常见。因此,在所有明显RH的评估中筛查假耐药是至关重要的,因为白大衣HTN的诊断不需要治疗,而药物不依从性将受益于识别和靶向依从性障碍。
The updated scientific statement by the American Heart Association has defined resistant hypertension (HTN; RH) as uncontrolled blood pressure (BP) ≥ 130/80 mmHg, despite concurrent use of 3 anti-HTN drug classes comprising a calcium channel blocker, a blocker of renin-angiotensin system, and a thiazide diuretic, preferably chlorthalidone. Using the updated BP criteria, the prevalence of RH in the United States is found to be modestly increased by approximately 3–4% among treated population. Meta-analysis of observational studies have demonstrated that pseudo-RH from white coat HTN or medication nonadherence is as much common as the truly RH. Thus, screening for pseudo-resistance in the evaluation of all apparent RH is of utmost importance as diagnosis of white-coat HTN requires no treatment, while medication nonadherence would benefit from identifying and targeting barriers to adherence.
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发表时间: 2018-11
期刊: Hypertension (Dallas, Tex. : 1979)
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