Neck circumference as an independent predictive contributor to cardio-metabolic syndrome.
Neck circumference as an independent predictive contributor to cardio-metabolic syndrome.
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颈围是心脏代谢综合征的独立预测因素
DOI：
10.1186/1475-2840-12-76
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发表时间：
2013-05-16
影响因子：
9.3
通讯作者：
Zhu HL
中科院分区：
文献类型：
--
作者：
Zhou JY;Ge H;Zhu MF;Wang LJ;Chen L;Tan YZ;Chen YM;Zhu HL
颈围（NC）对心脏代谢风险的预测潜力仍不确定。本研究的目的是调查NC是否独立有助于预测体重指数（BMI）以外的心脏代谢风险，在中国大规模人群中测量腰围（WC）和腰臀比（WHpR）于2009年5月至2010年4月期间在健康检查中心招募了20-85岁的男性2508人和女性1693人，测量了人体测量指标、生化和临床参数。采用受试者操作特征、偏相关分析和Logistic回归分析，分别对不同性别的人体测量指标与心血管代谢危险性的关系进行评价。男性与空腹血糖（r=0.250和0.261）、甘油三酯（r=0.240）、总胆固醇（r =0.143）和低密度脂蛋白胆固醇（r=0.088）呈负相关（r=-0.202）（均P<0.01）。除TC外，在女性中发现了类似的结果。NC代谢异常的AUC男性为0.558（LDL-C升高）~ 0.683（MS-rf），女性为0.596（LDL-C升高）~ 0.703（MS-rf）（P<0.01）。男性NC ≥37 cm、女性NC ≥33 cm为代谢综合征的最佳分界点。男性和女性NC的校正OR（95%CI）分别为1.29（1.12-1.48）和1.44（1.20-1.72）代谢综合征危险因素（MS-rf），1.15（1.01-1.32）和1.22（1.03-1.46）高血压，1.16（1.02-1.33）和1.42（1.18-1.71），1.26（1.06-1.50）和1.32（1.06-1.65）为DBP升高;女性中NC降低HDL-C的校正OR为1.29（1.10-1.51）.结论颈围与心血管代谢危险因素显著相关，在中国成年人中，颈围对心血管代谢危险的预测作用独立于传统的人体测量指标。
BackgroundThe predictive potentials of neck circumference (NC) for cardio-metabolic risks remain uncertain. The aim of this study was to investigate whether NC independently contributes to the prediction of cardio-metabolic risks beyond body mass index (BMI), waist circumference (WC) and waist to hip ratio (WHpR) in a large Chinese population.MethodsA total of 4201 participants (2508 men and 1693 women) aged 20-85 were recruited from the Health Examination Centre between May 2009 and April 2010, anthropometric indices, biochemical and clinical parameters were measured. Receiver operating characteristic, partial correlation and logistic regression analyses were employed to evaluate the association of the anthropometric indices to cardio-metabolic risks separately by gender.ResultsNeck circumference was positively correlated with SBP and DBP (r=0.250 and 0.261), fasting blood glucose (FBP) (r=0.177), TG (r=0.240), TC (r=0.143) and LDL-C (r=0.088) and negatively correlated with HDL-C (r=-0.202) in males (all P<0.01). Similar results were found in females with the exception of TC. The AUCs of NC for metabolic abnormalities ranged from 0.558 (Increased LDL-C) to 0.683 (MS-rf) in men and 0.596 (Increased LDL-C) to 0.703 (MS-rf) in women (P<0.01). The NC of ≥37 cm for men and ≥33 cm for women were the best cut-off points for metabolic syndrome. The adjusted ORs (95% CIs) of NC in men and women respectively were 1.29 (1.12-1.48) and 1.44 (1.20-1.72) for metabolic syndrome risk factors (MS-rf), 1.15 (1.01-1.32) and 1.22 (1.03-1.46) for high BP, 1.16 (1.02-1.33) and 1.42 (1.18-1.71) for increased TG, and 1.26 (1.06-1.50) and 1.32 (1.06-1.65) for increased FBP; the adjusted OR of NC in women for decreased HDL-C was 1.29 (1.10-1.51).ConclusionsNeck circumference was significantly associated with cardio-metabolic risk factors and independently contributed to the prediction of cardio-metabolic risks beyond the classical anthropometric indices in adults of China.
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影响因子：
7.1
作者：
WING, RR;JEFFERY, RW;FOLSOM, AR
通讯作者：
FOLSOM, AR
影响因子：
1.6
作者：
Ferrannini, Ele;Sironi, Anna Maria;Gastaldelli, Amalia
通讯作者：
Gastaldelli, Amalia
影响因子：
4.5
作者：
Seo JA;Kim BG;Cho H;Kim HS;Park J;Baik SH;Choi DS;Park MH;Jo SA;Koh YH;Han C;Kim NH
通讯作者：
Kim NH
影响因子：
5.8
作者：
Preis, Sarah Rosner;Massaro, Joseph M.;Fox, Caroline S.
通讯作者：
Fox, Caroline S.
DOI：
10.1038/oby.2001.61
发表时间：
2001-08-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Ben-Noun, L;Sohar, E;Laor, A
通讯作者：
Laor, A