Mechanical stimuli for left ventricular growth during pressure overload.
Mechanical stimuli for left ventricular growth during pressure overload.
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DOI：
10.1007/s11340-020-00643-z
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发表时间：
2021-01
影响因子：
2.4
通讯作者：
Lee LC
中科院分区：
文献类型：
--
作者：
Mojumder J;Choy JS;Leng S;Zhong L;Kassab GS;Lee LC
在压力过载的左心室（LV）中发生的生长的机械刺激（即应力或拉伸）并不确切。为了解决这个问题，我们研究了局部心室生长（以局部壁厚为指标）与主动脉结扎后机械刺激的局部急性变化之间的相关性。在主动脉结扎猪模型（n = 4）中，从基线和2周时的3D回波测量中提取LV几何数据。我们开发并校准了LV力学的动物特定有限元（FE）模型，以对抗基线时测量的压力和体积波形。在模拟压力超负荷的急性效应后，在三个正交材料方向（即，纤维、薄片和薄片-正常）。使用皮尔逊相关数（PCN）和斯皮尔曼等级相关数（SCN）量化机械量和相应的测量局部壁厚变化之间的相关性。结扎后2周，平均室间隔厚度从10.6 ± 2.92 mm降至9.49 ± 2.02 mm，而左室游离壁厚度从8.69 ± 1.64 mm增至9.4 ± 1.22 mm。有限元分析结果表明，生长与最大纤维应力（PCN = 0.5471，SCN = 0.5111）和平均板材法向应力（PCN= 0.5266，SCN = 0.5256）的变化有很强的相关性。然而，心肌伸展与生长没有很好的相关性。这些结果表明，纤维应力是压力超负荷时左心室生长的机械刺激。
The mechanical stimulus (i.e. stress or stretch) for growth occurring in the pressure-overloaded left ventricle (LV) is not exactly known. To address this issue, we investigate the correlation between local ventricular growth (indexed by local wall thickness) and the local acute changes in mechanical stimuli after aortic banding. LV geometric data were extracted from 3D echo measurements at baseline and 2 weeks in the aortic banding swine model (n = 4). We developed and calibrated animal-specific finite element (FE) model of LV mechanics against pressure and volume waveforms measured at baseline. After the simulation of the acute effects of pressure-overload, the local changes of maximum, mean and minimum myocardial stretches and stresses in three orthogonal material directions (i.e., fiber, sheet and sheet-normal) over a cardiac cycle were quantified. Correlation between mechanical quantities and the corresponding measured local changes in wall thickness was quantified using the Pearson correlation number (PCN) and Spearman rank correlation number (SCN). At 2 weeks after banding, the average septum thickness decreased from 10.6 ± 2.92mm to 9.49 ± 2.02mm, whereas the LV free-wall thickness increased from 8.69 ± 1.64mm to 9.4 ± 1.22mm. The FE results show strong correlation of growth with the changes in maximum fiber stress (PCN = 0.5471, SCN = 0.5111) and changes in the mean sheet-normal stress (PCN= 0.5266, SCN = 0.5256). Myocardial stretches, however, do not have good correlation with growth. These results suggest that fiber stress is the mechanical stimuli for LV growth in pressure-overload.
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DOI：
10.1002/wsbm.1330
发表时间：
2016-05
期刊：
Wiley interdisciplinary reviews. Systems biology and medicine
影响因子：
--
作者：
Lee LC;Kassab GS;Guccione JM
通讯作者：
Guccione JM
影响因子：
3.8
作者：
Bayer, J. D.;Blake, R. C.;Plank, G.;Trayanova, N. A.
通讯作者：
Trayanova, N. A.
影响因子：
3.8
作者：
Carruth, Eric D.;McCulloch, Andrew D.;Omens, Jeffrey H.
通讯作者：
Omens, Jeffrey H.
影响因子：
3.8
作者：
Charles, Christopher J.;Lee, Philip;Richards, A. Mark
通讯作者：
Richards, A. Mark
影响因子：
2.4
作者：
Kerckhoffs RC;Omens J;McCulloch AD
通讯作者：
McCulloch AD