Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring.
Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring.
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DOI：
10.1038/nutd.2012.31
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发表时间：
2012-12-17
影响因子：
6.1
通讯作者：
Reynolds, J. N.
中科院分区：
文献类型：
--
作者：
Dobson, C. C.;Mongillo, D. L.;Brien, D. C.;Stepita, R.;Poklewska-Koziell, M.;Winterborn, A.;Holloway, A. C.;Brien, J. F.;Reynolds, J. N.
怀孕期间饮酒会导致儿童一系列不良发育结果，称为胎儿酒精谱系障碍（FASD）。中枢神经系统损伤是慢性产前乙醇暴露（CPEE）的一种衰弱和广泛研究的表现。然而，CPEE也可能导致后代代谢途径的结构和功能缺陷。本研究验证了CPEE增加豚鼠后代全身肥胖和破坏胰腺结构的假设。妊娠豚鼠在整个妊娠期每周接受5天乙醇（每天4 g/kg母体体重）或等热量蔗糖/配对喂养（对照）。雄性和雌性CPEE后代在出生时表现出生长受限，随后在断奶前（出生后第1-7天）出现快速追赶生长期。年轻成年后代（PD 100 -140）的全身磁共振成像（MRI）显示CPEE产生的内脏和皮下脂肪增多。在处死时（PD 150 -200），CPEE后代的胰腺脂肪细胞面积也增加，β细胞胰岛素样免疫阳性面积减少，表明胰岛的胰岛素产生和/或分泌减少。CPEE导致后代肥胖和胰腺畸形增加，这可能意味着代谢综合征和2型糖尿病发展的风险增加。
Ethanol consumption during pregnancy can lead to a range of adverse developmental outcomes in children, termed fetal alcohol spectrum disorder (FASD). Central nervous system injury is a debilitating and widely studied manifestation of chronic prenatal ethanol exposure (CPEE). However, CPEE can also cause structural and functional deficits in metabolic pathways in offspring. This study tested the hypothesis that CPEE increases whole-body adiposity and disrupts pancreatic structure in guinea pig offspring. Pregnant guinea pigs received ethanol (4 g kg−1 maternal body weight per day) or isocaloric-sucrose/pair-feeding (control) for 5 days per week throughout gestation. Male and female CPEE offspring demonstrated growth restriction at birth, followed by a rapid period of catch-up growth before weaning (postnatal day (PD) 1–7). Whole-body magnetic resonance imaging (MRI) in young adult offspring (PD100–140) revealed increased visceral and subcutaneous adiposity produced by CPEE. At the time of killing (PD150–200), CPEE offspring also had increased pancreatic adipocyte area and decreased β-cell insulin-like immunopositive area, suggesting reduced insulin production and/or secretion from pancreatic islets. CPEE causes increased adiposity and pancreatic dysmorphology in offspring, which may signify increased risk for the development of metabolic syndrome and type 2 diabetes mellitus.
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影响因子：
39.2
作者：
GINSBERG, H;OLEFSKY, J;REAVEN, GM
通讯作者：
REAVEN, GM
影响因子：
5.8
作者：
Fan, Amy Z.;Russell, Marcia;Mokdad, Ali H.
通讯作者：
Mokdad, Ali H.
影响因子：
2.5
作者：
DOBBING, J;SANDS, J
通讯作者：
SANDS, J
影响因子：
4.2
作者：
Dorn, JM;Hovey, K;Trevisan, M
通讯作者：
Trevisan, M
影响因子：
3.3
作者：
Chen, L;Nyomba, BLG
通讯作者：
Nyomba, BLG