ChromothripsisDB: a curated database of chromothripsis
ChromothripsisDB: a curated database of chromothripsis
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ChromothripsisDB：一个精心策划的 Chromothripsis 数据库
DOI：
10.1093/bioinformatics/btv757
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发表时间：
2016-05
期刊：
影响因子：
5.8
通讯作者：
Haoyang Cai
中科院分区：
文献类型：
--
作者：
Jian Yang;Gaofeng Deng;Haoyang Cai
未标记
染色体断裂是一种单一的灾难性事件，可导致局限于一条或几条染色体的大规模基因组重排。它提供了癌症发展的另一种范式，并改变了癌症逐步发展的传统观点。chromothripsis的机制及其对肿瘤发生的具体影响仍然知之甚少，需要进一步检查大量已鉴定的chromothripsis样本。不幸的是，这些数据很难获得，因为它们分散在多个出版物中，有不同的格式和描述，或者隐藏在数字和补充材料中。为了改善对这些数据的访问并促进荟萃分析，我们开发了ChromothripsisDB，这是一个手动管理的数据库，包含所有已发表的Chromothripsis病例和相关基因组畸变的统一描述。目前，423 chromothripsis样本代表107篇研究文章被纳入我们的数据库。ChromothripsisDB是一个非凡的资源，用于挖掘Chromothripsis的现有知识，并将有助于识别这种现象所涉及的机制。
可用性和执行
ChromothripsisDB可在http://cgma.scu.edu.cn/ChromothripsisDB上免费获得。联系方式：haoyang. scu.edu.cn
补充资料
补充数据可在在线生物信息学上获取。
UNLABELLED
Chromothripsis is a single catastrophic event that can lead to massive genomic rearrangements confined to one or a few chromosomes. It provides an alternative paradigm in cancer development and changes the conventional view that cancer develops in a stepwise progression. The mechanisms underlying chromothripsis and their specific impact on tumorigenesis are still poorly understood, and further examination of a large number of identified chromothripsis samples is needed. Unfortunately, this data are difficult to access, as they are scattered across multiple publications, come in different formats and descriptions, or are hidden in figures and supplementary materials. To improve access to this data and promote meta-analysis, we developed ChromothripsisDB, a manually curated database containing a unified description of all published chromothripsis cases and relevant genomic aberrations. Currently, 423 chromothripsis samples representing 107 research articles are included in our database. ChromothripsisDB represents an extraordinary resource for mining the existing knowledge of chromothripsis, and will facilitate the identification of mechanisms involved in this phenomenon.
AVAILABILITY AND IMPLEMENTATION
ChromothripsisDB is freely available at http://cgma.scu.edu.cn/ChromothripsisDB CONTACT: haoyang.cai@scu.edu.cn
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
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影响因子：
64.5
作者：
Rausch T;Jones DT;Zapatka M;Stütz AM;Zichner T;Weischenfeldt J;Jäger N;Remke M;Shih D;Northcott PA;Pfaff E;Tica J;Wang Q;Massimi L;Witt H;Bender S;Pleier S;Cin H;Hawkins C;Beck C;von Deimling A;Hans V;Brors B;Eils R;Scheurlen W;Blake J;Benes V;Kulozik AE;Witt O;Martin D;Zhang C;Porat R;Merino DM;Wasserman J;Jabado N;Fontebasso A;Bullinger L;Rücker FG;Döhner K;Döhner H;Koster J;Molenaar JJ;Versteeg R;Kool M;Tabori U;Malkin D;Korshunov A;Taylor MD;Lichter P;Pfister SM;Korbel JO
通讯作者：
Korbel JO
影响因子：
7
作者：
Kim TM;Xi R;Luquette LJ;Park RW;Johnson MD;Park PJ
通讯作者：
Park PJ
影响因子：
64.5
作者：
Liu P;Erez A;Nagamani SC;Dhar SU;Kołodziejska KE;Dharmadhikari AV;Cooper ML;Wiszniewska J;Zhang F;Withers MA;Bacino CA;Campos-Acevedo LD;Delgado MR;Freedenberg D;Garnica A;Grebe TA;Hernández-Almaguer D;Immken L;Lalani SR;McLean SD;Northrup H;Scaglia F;Strathearn L;Trapane P;Kang SH;Patel A;Cheung SW;Hastings PJ;Stankiewicz P;Lupski JR;Bi W
通讯作者：
Bi W
影响因子：
4.4
作者：
Cai H;Kumar N;Bagheri HC;von Mering C;Robinson MD;Baudis M
通讯作者：
Baudis M
影响因子：
64.5
作者：
Stephens PJ;Greenman CD;Fu B;Yang F;Bignell GR;Mudie LJ;Pleasance ED;Lau KW;Beare D;Stebbings LA;McLaren S;Lin ML;McBride DJ;Varela I;Nik-Zainal S;Leroy C;Jia M;Menzies A;Butler AP;Teague JW;Quail MA;Burton J;Swerdlow H;Carter NP;Morsberger LA;Iacobuzio-Donahue C;Follows GA;Green AR;Flanagan AM;Stratton MR;Futreal PA;Campbell PJ
通讯作者：
Campbell PJ