Requirement of B cells for generating CD4+ T cell memory.
Requirement of B cells for generating CD4+ T cell memory.
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DOI：
10.4049/jimmunol.0802501
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发表时间：
2009-02-15
期刊：
影响因子：
--
通讯作者：
Ahmed R
中科院分区：
文献类型：
--
作者：
Whitmire JK;Asano MS;Kaech SM;Sarkar S;Hannum LG;Shlomchik MJ;Ahmed R
B细胞可以通过直接呈递抗原或通过分泌结合抗原的抗体以形成免疫原性复合物来影响T细胞应答。证据表明，持续存在的抗原/抗体复合物传播长期的T细胞记忆;还有其他数据表明，记忆细胞可以在没有特异性抗原或MHC的情况下存活。在这里，B细胞和抗原/抗体复合物在T细胞对淋巴细胞性脉络丛脑膜炎病毒（LCMV）感染的反应中的作用进行了研究，使用B细胞缺陷或B细胞感受态小鼠。尽管急性感染后淋巴细胞正常扩增，但B细胞缺陷小鼠在收缩期迅速丧失了CD 4 + T细胞记忆，但CD 8 + T细胞记忆没有丧失。为了确定抗原/抗体复合物是否维持CD 4 + T细胞记忆，在具有B细胞但既没有LCMV特异性抗体也没有LCMV免疫复合物沉积的B细胞转基因（mIg-Tg）小鼠中跟踪T细胞应答。与B细胞缺陷小鼠相反，mIg-Tg小鼠保留了功能性T辅助细胞记忆，表明B细胞选择性地保留了CD 4 + T细胞记忆，而与免疫复合物形成无关。丧失CD 4 + T细胞记忆的体内结果是B细胞缺陷小鼠不能解决慢性病毒感染。这些数据暗示了B细胞功能而不是抗体产生，其诱导长期保护性免疫。
B cells can influence T cell responses by directly presenting antigen or by secreting antibody that binds to antigen to form immunogenic complexes. Conflicting evidence suggests that persisting antigen/antibody complexes propagate long-term T cell memory; yet other data indicate that memory cells can survive without specific antigen or MHC. Here, the roles of B cells and antigen/antibody complexes in T cell responses to lymphocytic choriomeningitis virus (LCMV) infection were investigated using B cell-deficient or B cell-competent mice. Despite normal lymphocyte expansion after acute infection, B cell-deficient mice rapidly lost CD4+ T cell memory – but not CD8+ T cell memory – during the contraction phase. To determine whether antigen/antibody complexes sustain CD4+ T cell memory, T cell responses were followed in B cell-transgenic (mIg-Tg) mice that have B cells but neither LCMV-specific antibody nor LCMV-immune complex deposition. In contrast to B cell-deficient mice, mIg-Tg mice retained functional T-helper cell memory, indicating that B cells selectively preserve CD4+ T cell memory independently of immune-complex formation. An in vivo consequence of losing CD4+ T cell memory was that B cell-deficient mice were unable to resolve chronic virus infection. These data implicate a B cell function other than antibody production that induces long-term protective immunity.
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影响因子：
4.4
作者：
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