Lesions of the nucleus accumbens core modulate development of matching behavior.
Lesions of the nucleus accumbens core modulate development of matching behavior.
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DOI：
10.1186/1471-2202-15-55
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发表时间：
2014-04-30
期刊：
影响因子：
2.4
通讯作者：
Kobayashi K
中科院分区：
文献类型：
--
作者：
Kai N;Tsutsui Y;Kobayashi K
选择的发展是食欲反应表现的关键决定因素。给定具有不同强化率的两个选项，动物将它们的相对响应率与相对强化率相匹配（即，匹配行为）。先前的一项研究表明，在受过训练的动物中，丘脑核核心（AcbC）参与匹配行为的表现。然而，AcbC在获得匹配行为中的作用尚未得到解决。我们进行了一系列的实验，以检查的作用，AcbC的匹配行为的发展。仪器反应测定兴奋性毒性损伤的大鼠的AcbC。大鼠被给予两种选择，在并行可变间隔时间表下，这两种选择的相对强化率不同。更频繁地加强选项和替代选项的位置在会话之间随机切换。与假手术组相比，AcbC的损伤加速了匹配行为的发展。AcbC损伤的大鼠表现出更紧密的符合匹配规律比shams时，选项在相同的位置，在前一届会议（相同的条件），但不是当选项的位置已经切换（不同的条件）。AcbC大鼠在替代品之间切换行为的概率比假的小。强化后暂停不受AcbC病变的影响。无论是获得奖励的数量，也不是杠杆按下的数量是不同的AcbC损伤的大鼠和假的会话块。我们的研究结果表明，AcbC发挥了调节作用，在匹配行为的发展，通过切换概率，而不是感知奖励的大小。AcbC病变对相同和不同条件之间的匹配行为的差异效应表明自发恢复的影响，即在下一次会议开始时恢复到先前加强的选择，对AcbC病变大鼠匹配行为的发展。
The development of choice is a crucial determinant in the performance of appetitive responses. Given two options with different reinforcement rates, animals match their relative rate of responding to the relative rates of reinforcement (i.e., matching behavior). A previous study has shown that the nucleus accumbens core (AcbC) is involved in the performance of matching behavior in trained animals. However, the role of the AcbC in the acquisition of matching behavior has not been addressed. We conducted a series of experimental sessions to examine the role of the AcbC on the development of matching behavior. Instrumental responding was measured in rats with excitotoxic lesions of the AcbC. Rats were given two options that differed in the relative rate of reinforcement under concurrent variable-interval schedules. The locations of the more frequently reinforced option and the alternative option were randomly switched between sessions. Lesions of the AcbC accelerated the development of matching behavior compared to the sham-operated group. The AcbC-lesioned rats exhibited closer conformity to the matching law than shams when the options were in the same positions as in the previous session (the same condition), but not when the option locations had been switched (the different condition). The AcbC rats showed smaller probabilities of switching behavior between alternatives than shams. Post-reinforcement pausing was not affected by the AcbC lesion. Neither numbers of rewards obtained nor number of lever presses were different between the AcbC-lesioned rats and shams over session blocks. Our results suggest that the AcbC plays a regulatory role in the development of matching behavior through switching probabilities rather than perception of reward magnitude. The differential effect of AcbC lesions on the matching behavior between the same and different conditions suggests influence of the spontaneous recovery, that is, reversion to a previously reinforced choice at the beginning of the next session, on the development of matching behavior in the AcbC-lesioned rats.
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