Schwann cells and trigeminal neuralgia.

Schwann cells and trigeminal neuralgia.
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雪旺细胞和三叉神经痛。

DOI:
10.1177/1744806920963809
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发表时间:
2020-01
期刊:
影响因子:
3.3
通讯作者:
Liu ZX
Liu ZX
中科院分区:
医学3区
文献类型:
--
作者:
Liao JY;Zhou TH;Chen BK;Liu ZX

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参考文献

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雪旺细胞是周围神经髓鞘的组成部分,其支持和包裹轴突。当三叉神经损伤时,雪旺细胞被激活并通过吞噬髓鞘和分泌各种神经营养因子引起三叉神经痛。此外,许旺细胞可以修复受损的神经,从而缓解三叉神经痛。在这里,我们简要地描述了神经损伤后雪旺细胞的发育和激活。阐述了三叉神经痛的发生、调节和治疗,指出了目前研究的不足和今后的研究方向。
Schwann cells are components of the peripheral nerve myelin sheath, which supports and nourishes axons. Upon injury of the trigeminal nerve, Schwann cells are activated and cause trigeminal neuralgia by engulfing the myelin sheath and secreting various neurotrophic factors. Further, Schwann cells can repair the damaged nerve and thus alleviate trigeminal neuralgia. Here, we briefly describe the development and activation of Schwann cells after nerve injury. Moreover, we expound on the occurrence, regulation, and treatment of trigeminal neuralgia; further, we point out the current research deficiencies and future research directions.
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