Chronic Unilateral Hearing Loss Disrupts Neural Tuning to Sound-Source Azimuth in the Rat Primary Auditory Cortex
Chronic Unilateral Hearing Loss Disrupts Neural Tuning to Sound-Source Azimuth in the Rat Primary Auditory Cortex
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慢性单侧听力损失扰乱了大鼠初级听觉皮层对声源方位角的神经调节
DOI：
10.3389/fnins.2019.00477
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发表时间：
2019-05
影响因子：
4.3
通讯作者：
Zhang Jiping
中科院分区：
文献类型：
--
作者：
Wang Xiuwen;Liu Jing;Zhang Jiping
准确的声音定位需要正常的双耳输入和声音空间位置的精确听觉神经元表示。以往的研究表明，单侧听力损失严重损害声音定位能力。然而，潜在的神经机制尚未完全理解。本研究旨在探讨慢性单侧传导性听力损失（UCHL）对初级听皮层（AI）声源方位神经调谐的影响。通过去除幼年（P14）和成年（P57）大鼠右耳的鼓膜和锤骨操作UCHL。我们记录的方位角调谐神经元在左AI对侧的手术耳在两组大鼠经历了2个月的UCHL，并在左AI的年龄匹配的对照组大鼠。我们发现，对照组大鼠的AI神经元对来自对侧方位的声音表现出明显的偏好。然而，UCHL削弱了对侧方位的皮层神经元的代表在手术侧和加强同侧方位的皮层神经元的代表在完整的耳侧。这种作用在幼年UCHL大鼠中比在成年UCHL大鼠中更强。此外，UCHL降低AI神经元的方位选择性和方位敏感性，这种影响在成年UCHL大鼠比在青年UCHL大鼠更强。这些发现突出了一个显着的年龄相关的经验依赖性可塑性的神经调谐声源方位在AI，并暗示了慢性UCHL的声音定位能力的影响的神经机制。
Accurate sound localization requires normal binaural input and precise auditory neuronal representation of sound spatial locations. Previous studies showed that unilateral hearing loss profoundly impaired the sound localization abilities. However, the underlying neural mechanism is not fully understood. Here, we investigated how chronic unilateral conductive hearing loss (UCHL) affected the neural tuning to sound source azimuth in the primary auditory cortex (AI). The UCHL was manipulated by the removal of tympanic membrane and malleus in the right ear of young (P14) rats and adult (P57) rats. We recorded the azimuth tuning of neurons in the left AI contralateral to the operated ear in the two groups of rats that experienced 2 months of UCHL, and in the left AI of age-matched control rats. We found that AI neurons in control rats showed predominant preference to sound from contralateral azimuths. However, UCHL weakened the cortical neuronal representation of contralateral azimuths on the operated ear side and strengthened the cortical neuronal representation of ipsilateral azimuths on the intact ear side. This effect was stronger in rats with UCHL at young age than in rats with UCHL in adulthood. Moreover, UCHL degraded the azimuth selectivity and azimuth sensitivity of AI neurons, and this effect was stronger in rats with UCHL in adulthood than in rats with UCHL at young age. These findings highlight a remarkable age-related experience-dependent plasticity of neural tuning to sound source azimuth in AI, and imply a neural mechanism for the impacts of chronic UCHL on sound localization abilities.
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影响因子：
7.7
作者：
Yao JD;Sanes DH
通讯作者：
Sanes DH
影响因子：
2.5
作者：
R. Reale;R. Jenison;J. Brugge
通讯作者：
R. Reale;R. Jenison;J. Brugge
环境丰富可以挽救早期噪声暴露引起的皮质神经元听觉时间分辨率下降
影响因子：
3.4
作者：
Jiang, Cuiping;Xu, Xiaoxiao;Zhang, Jiping
通讯作者：
Zhang, Jiping
影响因子：
2.5
作者：
Doron, NN;Ledoux, JE;Semple, MN
通讯作者：
Semple, MN
影响因子：
2.5
作者：
Barone, P;Clarey, JC;Imig, TJ
通讯作者：
Imig, TJ