Modulating Mechanical and Shape-Memory Properties while Mitigating Degradation-Induced Inflammation of Polylactides by Pendant Aspirin Incorporation.
Modulating Mechanical and Shape-Memory Properties while Mitigating Degradation-Induced Inflammation of Polylactides by Pendant Aspirin Incorporation.
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DOI：
10.1021/acsami.1c06178
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发表时间：
2021-05-19
影响因子：
9.5
通讯作者：
Song J
中科院分区：
文献类型：
--
作者：
Xu X;Zhang J;Filion TM;Akalin A;Song J
Synergistically modulating mechanical properties and improving shape-memory performance while mitigating degradation-induced chronic inflammation of polylactide (PLA)-based implants for biomedical applications remains elusive. We test the hypothesis that copolymerizing aspirin-functionalized glycolide with D, L-lactide could enhance the thermal processing, toughness, and shape memory efficiency of the copolymer while mitigating local inflammatory responses upon its degradation. The content of pendant aspirin was readily modulated by monomer feeds during ring opening polymerization, and the copolymers with ~10% or less aspirin pendants exhibited gigapascal-tensile moduli at body temperature and significantly improved fracture toughness and energy dissipation that positively correlated with the aspirin pendant content. The copolymers also exhibited excellent thermal-healing and shape memory efficacy, achieving >97% temporary shape fixing ratio at room temperature and facile shape recovery at 50-65 °C. These drastic improvements were attributed to the dynamic hydrophobic aggregations among aspirin pendants that strengthen glassy-state physical entanglement of PLA while readily dissociate under stress/thermal activation. When subcutaneously implanted, the copolymers mitigated degradation-induced inflammation due to concomitant hydrolytic release of aspirin without suppressing early acute inflammatory responses. The incorporation of aspirin pendants in PLA represents a straightforward and innovative strategy to enhance the toughness, shape memory performance and in vivo safety of this important class of thermoplastics for biomedical applications.
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影响因子：
4.6
作者：
Ghavimi MA;Bani Shahabadi A;Jarolmasjed S;Memar MY;Maleki Dizaj S;Sharifi S
通讯作者：
Sharifi S
影响因子：
4.6
作者：
Lebre F;Sridharan R;Sawkins MJ;Kelly DJ;O'Brien FJ;Lavelle EC
通讯作者：
Lavelle EC
影响因子：
1.9
作者：
Lozhkin, Boris A.;Shlyakhtin, Andrey V.;Nifant'ev, Ilya E.
通讯作者：
Nifant'ev, Ilya E.
DOI：
10.1002/jab.770040103
发表时间：
1993-03-01
期刊：
JOURNAL OF APPLIED BIOMATERIALS
影响因子：
--
作者：
SUGANUMA, J;ALEXANDER, H
通讯作者：
ALEXANDER, H
影响因子：
9.5
作者：
Visalakshan, Rahul M.;MacGregor, Melanie N.;Vasilev, Krasimir
通讯作者：
Vasilev, Krasimir