Ultrastructural and biochemical characterization of autonomic neuropathy in rats with chronic streptozotocin diabetes.
Ultrastructural and biochemical characterization of autonomic neuropathy in rats with chronic streptozotocin diabetes.
复制标题
慢性链脲佐菌素糖尿病大鼠自主神经病变的超微结构和生化特征。
DOI：
10.1097/00005072-198609000-00004
复制
发表时间：
1986
影响因子：
3.2
通讯作者：
Plurad,SB
中科院分区：
文献类型：
--
作者：
Schmidt,RE;Plurad,SB
Alterations in the extrinsic innervation of the alimentary tract and in various sympathetic autonomic ganglia were examined using quantitative ultrastructural and biochemical methods in streptozotocin diabetic rats maintained without treatment for 9–15 months. Ileal mesenteric nerves of 13–15 month diabetics showed the characteristic alterations of neuroaxonal dystrophy qualitatively similar to changes seen in this system in animals which were diabetic for shorter durations. Dystrophic axonopathy was not accompanied by significant axonal loss or atrophy. Dystrophic axons, presumably involving presynaptic elements, also were increased in frequency in the superior mesenteric ganglia, but not in the superior cervical ganglia, of animals diabetic for various durations. In addition, the superior mesenteric ganglia of diabetic animals contained an increased number of postsynaptic dendritic processes which were dilated by unusual tubular profiles. These ganglionic alterations were not accompanied by changes in the activity of the presynaptic cholinergic marker enzyme, choline acetyltransferase. The activity of the noradrenergic marker enzyme, dopamine-beta-hydroxylase, was unaltered in diabetic superior mesenteric ganglia compared to controls, but showed a 30-40% decrease in diabetic superior cervical ganglia, in which site it was unaccompanied by neuronal loss, atrophy, or ultrastructural alterations.
登录
查看更多内容
银屑病表皮的角蛋白多肽。
DOI：
10.1111/1523-1747.ep12541529
发表时间：
1978
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
H. Baden;N. McGilvray;C. K. Cheng;L. Lee;J. Kubilus
通讯作者：
J. Kubilus
银屑病的细胞动力学
影响因子：
10.3
作者：
M. Heenen;P. Galand
通讯作者：
P. Galand
影响因子：
10.3
作者：
BERNARD, BA;ROBINSON, SM;DARMON, M
通讯作者：
DARMON, M
人类角质形成细胞培养物。
DOI：
10.1172/jci112317
发表时间：
1986
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Staiano-Coico,L;Higgins,PJ;Darzynkiewicz,Z;Kimmel,M;Gottlieb,AB;Pagan-Charry,I;Madden,MR;Finkelstein,JL;Hefton,JM
通讯作者：
Hefton,JM
细胞总 RNA 含量：流式细胞术和紫外光谱之间的相关性。
影响因子：
3.2
作者：
K. Bauer;L. Dethlefsen
通讯作者：
L. Dethlefsen