Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo.
Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo.
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DOI：
10.1126/science.aaf1279
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发表时间：
2016-05-20
期刊：
影响因子：
--
通讯作者：
Nussenzweig MC
中科院分区：
文献类型：
--
作者：
Lu CL;Murakowski DK;Bournazos S;Schoofs T;Sarkar D;Halper-Stromberg A;Horwitz JA;Nogueira L;Golijanin J;Gazumyan A;Ravetch JV;Caskey M;Chakraborty AK;Nussenzweig MC
抗逆转录病毒药物和抗体通过干扰病毒的生命周期来限制HIV-1感染。此外，抗体还具有引导宿主免疫效应细胞杀死HIV-1感染细胞的潜力。通过被动施用3BNC 117（一种广泛中和抗体（bNAb））对感染个体中HIV-1抑制的动力学的检查表明，抗体的作用不仅限于游离病毒清除和阻断新感染，还包括加速感染细胞清除。与这些观察结果一致，我们发现bNAb可以靶向感染患者病毒的CD 4 + T细胞，并通过人源化小鼠模型中需要FcγR参与的机制降低其体内半衰期。结果表明，被动免疫治疗可以加速HIV-1感染细胞的清除。
Anti-retroviral drugs and antibodies limit HIV-1 infection by interfering with the viral life-cycle. In addition, antibodies also have the potential to guide host immune effector cells to kill HIV-1 infected cells. Examination of the kinetics of HIV-1 suppression in infected individuals by passively administered 3BNC117, a broadly neutralizing antibody (bNAb), suggested that the effects of the antibody are not limited to free viral clearance and blocking new infection, but also include acceleration of infected cell clearance. Consistent with these observations, we find that bNAbs can target CD4+ T cells infected with patient viruses and decrease their in vivo half-lives by a mechanism that requires FcγR engagement in a humanized mouse model. The results indicate that passive immunotherapy can accelerate elimination of HIV-1 infected cells.
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DOI：
10.1084/jem.20151267
发表时间：
2015-08-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bournazos S;DiLillo DJ;Ravetch JV
通讯作者：
Ravetch JV
影响因子：
4.3
作者：
De Boer RJ;Ribeiro RM;Perelson AS
通讯作者：
Perelson AS
影响因子：
1
作者：
Pollara J;Bonsignori M;Moody MA;Pazgier M;Haynes BF;Ferrari G
通讯作者：
Ferrari G
影响因子：
64.8
作者：
Caskey M;Klein F;Lorenzi JC;Seaman MS;West AP Jr;Buckley N;Kremer G;Nogueira L;Braunschweig M;Scheid JF;Horwitz JA;Shimeliovich I;Ben-Avraham S;Witmer-Pack M;Platten M;Lehmann C;Burke LA;Hawthorne T;Gorelick RJ;Walker BD;Keler T;Gulick RM;Fätkenheuer G;Schlesinger SJ;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
20.3
作者：
Horton, Holly M.;Bernett, Matthew J.;Zhukovsky, Eugene A.
通讯作者：
Zhukovsky, Eugene A.