Marital status is associated with survival of patients with astrocytoma
Marital status is associated with survival of patients with astrocytoma
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婚姻状况与星形细胞瘤患者的生存相关
DOI：
10.1016/j.jocn.2018.07.005
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发表时间：
2018-10
影响因子：
2
通讯作者：
zhao yanxin
中科院分区：
文献类型：
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作者：
zhao yanxin
婚姻状况对星形细胞瘤患者预后的影响还没有被充分研究。在这项研究中，我们调查了婚姻状况和星形细胞瘤生存的关系。我们从监测、流行病学和最终结果（SEER）数据库中提取了2000年后确诊的符合条件的星形细胞瘤患者。婚姻状况分为已婚、离婚/分居、丧偶和单身。采用Kaplan-Meier log-rank检验比较OS和CSS的差异，并采用多变量考克斯回归分析OS和CSS的危险因素。根据2016年WHO分级、诊断年份、中位家庭收入和手术状态进行亚组分析，以探讨婚姻状况与不同性别、年龄、种族、组织学类型患者的相关性。共有43，324名符合条件的患者入选。单身、已婚、离婚/分居和丧偶患者的中位总生存期分别为17、11、9和3个月。虽然单身患者似乎有最长的总生存期，在调整其他协变量后，已婚患者的OS和CSS最好，而离婚/分居或丧偶患者的CSS最差。此外，亚组分析显示了一些有趣的结果，如CSS显示单身和已婚女性之间没有差异（P = 0.122）。总之，婚姻状况是星形细胞瘤患者的独立预后因素。医疗保健系统应该意识到，婚姻流产的患者需要更多的社会和生理支持。
The prognostic role of marital status in patients with astrocytoma has not been fully explored. In this study we investigated the association of marital status and survival of astrocytoma. We extracted the eligible patients with astrocytoma diagnosed after 2000 from the Surveillance, Epidemiology, and End Results (SEER) database. The marital status was classified into married, divorced/separated, widowed, and single. The differences in OS and CSS were compared using the Kaplan-Meier log-rank test, and multivariate Cox regression was applied to analyze the risk factors for OS and CSS. Subgroup analyses were conducted to explore the association of marital status with patients in different sex, age, race, histologic type based on 2016 WHO grade, year of diagnosis, median household income and surgery status. A total of 43, 324 eligible patients were included. The median overall survival is 17, 11, 9, 3 months in single, married, divorced/separated patients, and widowed patients, respectively. Although single patients seemed to have the longest overall survival, after adjusted for other co-variables, married patients had the best OS and CSS compared with others, while divorced/separated or widowed patients had the worst CSS in different subgroups. Furthermore, subgroup analyses revealed some interesting results such as the CSS showed no difference between single and married for women (P = 0.122). In conclusion, marital status was an independent prognostic factor for astrocytoma patients. The healthcare system should aware of that patients with an aborted marriage need more social and physiological support.
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