Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.
Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.
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DOI：
10.1093/toxsci/kfn121
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Meyer JN
中科院分区：
文献类型：
--
作者：
Leung MC;Williams PL;Benedetto A;Au C;Helmcke KJ;Aschner M;Meyer JN
秀丽隐杆线虫已成为神经生物学、发育生物学和遗传学等领域的重要动物模型。这种动物模型的特点，有助于其成功，包括其遗传操纵性，不变和充分描述的发育程序，良好的特征基因组，易于维护，短而多产的生命周期，和小的身体尺寸。这些相同的特性导致了C的使用越来越多。elegans在毒理学中的应用，无论是机制研究还是高通量筛选方法。我们描述了一些已经在神经毒理学、遗传毒理学和环境毒理学领域进行的研究，以及用C.包括全基因组筛选毒性分子靶点和新化学品的快速毒性评估。我们主张增加C的作用。elegans在毒理学研究中补充其他模型系统。
The nematode Caenorhabditis elegans has emerged as an important animal model in various fields including neurobiology, developmental biology, and genetics. Characteristics of this animal model that have contributed to its success include its genetic manipulability, invariant and fully described developmental program, well-characterized genome, ease of maintenance, short and prolific life cycle, and small body size. These same features have led to an increasing use of C. elegans in toxicology, both for mechanistic studies and high-throughput screening approaches. We describe some of the research that has been carried out in the areas of neurotoxicology, genetic toxicology, and environmental toxicology, as well as high-throughput experiments with C. elegans including genome-wide screening for molecular targets of toxicity and rapid toxicity assessment for new chemicals. We argue for an increased role for C. elegans in complementing other model systems in toxicological research.
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影响因子：
5.3
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