Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.
Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.
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DOI：
10.1038/hr.2013.45
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发表时间：
2013-10
影响因子：
5.4
通讯作者：
Sutton-Tyrrell, Kim
中科院分区：
文献类型：
--
作者：
Cooper, Jennifer N.;Fried, Linda;Tepper, Ping;Barinas-Mitchell, Emma;Conroy, Molly B.;Evans, Rhobert W.;Brooks, Maria Mori;Woodard, Genevieve A.;Sutton-Tyrrell, Kim
最近的数据表明，过量的循环醛固酮促进心脏代谢下降。体重减轻可能会降低醛固酮水平，但在血压正常的成年人中几乎没有纵向数据。我们的目的是确定在血压正常的超重/肥胖年轻人中，血清醛固酮的降低是否与肥胖相关因素的有利变化相关，而与钠排泄的变化无关。我们在一项临床试验中研究了285名超重/肥胖的年轻成人参与者（体重指数（BMI）≥ 25且< 40 kg/m2，年龄20-45岁），研究了为期一年的饮食和体力活动干预（有或无钠限制）对血管健康的影响。在基线、6个月、12个月和24个月测量体重、血清醛固酮、24小时钠和钾排泄量以及肥胖相关因素。体重减轻在6个月（7%）、12个月（6%）和24个月（4%）时显著（所有p<0.0001）。在校正了基线年龄、性别、人种、干预组、基线后的时间以及钠和钾排泄的模型中，醛固酮的降低与C反应蛋白、瘦素、胰岛素、胰岛素抵抗的稳态评估、心率、紧张性心脏交感迷走神经平衡的降低以及脂联素的增加相关（所有p<0.05）。在基线时患有代谢综合征（MetS）的亚组（n=98）中，体重减轻和大腿肌间脂肪（IMAT）减少与醛固酮减少相关（MetS x体重减轻p=0.04，MetS x IMAT变化p=0.04）。肥胖相关因素的有利变化与年轻人中醛固酮的减少有关，除了超重之外没有危险因素，这是一个重要的发现，因为醛固酮是一个重要的心脏代谢危险因素。
Recent data suggest excess circulating aldosterone promotes cardiometabolic decline. Weight loss may lower aldosterone levels, but little longitudinal data is available in normotensive adults. We aimed to determine if, independent of changes in sodium excretion, reductions in serum aldosterone are associated with favorable changes in obesity-related factors in normotensive overweight/obese young adults. We studied 285 overweight/obese young adult participants (body mass index (BMI) ≥ 25 and < 40 kg/m2, age 20–45 years) in a clinical trial examining the effects of a one year diet and physical activity intervention with or without sodium restriction on vascular health. Body weight, serum aldosterone, 24-hr sodium and potassium excretion, and obesity-related factors were measured at baseline, 6, 12, and 24 months. Weight loss was significant at 6 (7%), 12 (6%), and 24 months (4%) (all p<0.0001). Decreases in aldosterone were associated with decreases in C-reactive protein, leptin, insulin, homeostasis assessment of insulin resistance, heart rate, tonic cardiac sympathovagal balance, and increases in adiponectin (all p<0.05) in models adjusting for baseline age, sex, race, intervention arm, time since baseline, and sodium and potassium excretion. Weight loss and reductions in thigh intermuscular fat (IMAT) were associated with decreases in aldosterone in the subgroup (n=98) with metabolic syndrome (MetS) at baseline (MetS x weight loss p=0.04, MetS x change in IMAT p=0.04). Favorable changes in obesity-related factors are associated with reductions in aldosterone in young adults with no risk factors besides excess weight, an important finding given aldosterone’s emergence as an important cardiometabolic risk factor.
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影响因子：
8.9
作者：
Dorresteijn, J. A. N.;Visseren, F. L. J.;Spiering, W.
通讯作者：
Spiering, W.
影响因子：
8.3
作者：
Engeli, S;Bohnke, J;Sharma, AM
通讯作者：
Sharma, AM
DOI：
10.3317/jraas.2006.004
发表时间：
2006-03-01
影响因子：
2.9
作者：
Nehme, Jobnny;Mercier, Nathalie;Lacolley, Patrick
通讯作者：
Lacolley, Patrick
影响因子：
12.3
作者：
Cooper, Jennifer N.;Tepper, Ping;Sutton-Tyrrell, Kim
通讯作者：
Sutton-Tyrrell, Kim
影响因子：
4.9
作者：
Furuhashi, M;Ura, N;Shimamoto, K
通讯作者：
Shimamoto, K