Development of a Comprehensive Osteochondral Allograft MRI Scoring System (OCAMRISS) with Histopathologic, Micro-Computed Tomography, and Biomechanical Validation.
Development of a Comprehensive Osteochondral Allograft MRI Scoring System (OCAMRISS) with Histopathologic, Micro-Computed Tomography, and Biomechanical Validation.
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DOI：
10.1177/1947603513514436
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发表时间：
2014-01-01
期刊：
影响因子：
2.8
通讯作者：
Chung CB
中科院分区：
文献类型：
--
作者：
Chang EY;Pallante-Kichura AL;Bae WC;Du J;Statum S;Wolfson T;Gamst AC;Cory E;Amiel D;Bugbee WD;Sah RL;Chung CB
描述并应用半定量MRI评分系统，用于骨软骨同种异体移植物修复膝关节软骨缺损的多特征分析，并使用山羊修复模型将该评分系统与组织病理学、显微计算机断层扫描（µCT）和生物力学参考标准相关联。在14只成年山羊的每个膝关节中植入2个骨软骨同种异体移植物：一个在股骨内侧髁，一个在股骨外侧髁。在12个月时，对山羊实施安乐死并进行MRI。两名设盲的放射科医生独立评定了每个移植物的9个主要特征，包括软骨信号、填充、边缘整合、表面一致性、钙化软骨完整性、软骨下骨板一致性、软骨下骨髓信号、骨整合和囊性变化的存在。还评估了关节的四个辅助特征，包括对向软骨、关节撕裂、滑膜炎和脂肪垫瘢痕。与组织学和µCT参考标准以及生物力学测量进行比较。评估观察者间一致性和与参比标准品的一致性。适当时使用Cohen κ、斯皮尔曼相关性和Kruskal-Wallis检验。除了软骨边缘整合（κ = 0.6）外，每个MRI特征与参考标准的比较基本一致（κ > 0.6，P < 0.001）。MRI评分与参考标准评分呈显著正相关（ρ = 0.86，P < 0.01）。骨软骨移植物MRI评分系统对同种异体移植物类型之间的结果差异敏感。我们已经描述了一种用于骨软骨同种异体移植物的综合MRI评分系统，并通过组织病理学和µCT参考标准以及生物力学压痕测试验证了该评分系统。
To describe and apply a semiquantitative MRI scoring system for multifeature analysis of cartilage defect repair in the knee by osteochondral allografts and to correlate this scoring system with histopathologic, micro–computed tomography (µCT), and biomechanical reference standards using a goat repair model. Fourteen adult goats had 2 osteochondral allografts implanted into each knee: one in the medial femoral condyle and one in the lateral trochlea. At 12 months, goats were euthanized and MRI was performed. Two blinded radiologists independently rated 9 primary features for each graft, including cartilage signal, fill, edge integration, surface congruity, calcified cartilage integrity, subchondral bone plate congruity, subchondral bone marrow signal, osseous integration, and presence of cystic changes. Four ancillary features of the joint were also evaluated, including opposing cartilage, meniscal tears, synovitis, and fat-pad scarring. Comparison was made with histologic and µCT reference standards as well as biomechanical measures. Interobserver agreement and agreement with reference standards was assessed. Cohen’s κ, Spearman’s correlation, and Kruskal-Wallis tests were used as appropriate. There was substantial agreement (κ > 0.6, P < 0.001) for each MRI feature and with comparison against reference standards, except for cartilage edge integration (κ = 0.6). There was a strong positive correlation between MRI and reference standard scores (ρ = 0.86, P < 0.01). Osteochondral allograft MRI scoring system was sensitive to differences in outcomes between the types of allografts. We have described a comprehensive MRI scoring system for osteochondral allografts and have validated this scoring system with histopathologic and µCT reference standards as well as biomechanical indentation testing.
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影响因子：
--
作者：
Hwang, Jennifer;Bae, Won C.;Shieu, Wendy;Lewis, Chad W.;Bugbee, William D.;Sah, Robert L.
通讯作者：
Sah, Robert L.
DOI：
10.1016/s0749-8063(97)90124-9
发表时间：
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影响因子：
4.7
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2.8
作者：
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影响因子：
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作者：
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