Eye-blink conditioning deficits indicate temporal processing abnormalities in schizophrenia.
Eye-blink conditioning deficits indicate temporal processing abnormalities in schizophrenia.
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DOI：
10.1016/j.schres.2009.03.016
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发表时间：
2009-06
影响因子：
4.5
通讯作者：
Hetrick, William P.
中科院分区：
文献类型：
--
作者：
Bolbecker, Amanda R.;Mehta, Crystal S.;Edwards, Chad R.;Steinmetz, Joseph E.;O'Donnell, Brian F.;Hetrick, William P.
理论模型表明，精神分裂症的症状可能是由于与小脑相关的调节系统功能失调所致。尽管人们早就知道小脑在联想学习和运动计时中发挥着关键作用，但最近的证据表明它也在非运动心理过程中发挥着作用。事实上，精神分裂症的小脑异常与认知功能障碍和长期预后不良有关。为了检验精神分裂症与小脑功能障碍相关的假设，我们对 62 名精神分裂症患者和 62 名年龄匹配的非精神病对照受试者进行了小脑依赖性眨眼延迟条件反射检查。条件刺激为 400 毫秒的音调，并与 50 毫秒的非条件刺激吹气共同终止。一部分参与者（25 名精神分裂症患者和 29 名对照者）也完成了韦克斯勒简略智力量表。患有精神分裂症的参与者表现出较低的眨眼调节率，包括较早（适应性较差）的条件反应潜伏期。在非精神病对照受试者中，认知功能与条件反应率相关，但在精神分裂症患者中则不然，并且这些相关性的程度在各组之间存在显着差异。这些发现与精神分裂症模型一致，在该模型中，皮质-小脑-丘脑-皮质（CCTC）大脑回路的破坏被认为是该疾病特征性认知碎片的基础。
Theoretical models suggest that symptoms of schizophrenia may be due to a dysfunctional modulatory system associated with the cerebellum. Although it has long been known that the cerebellum plays a critical role in associative learning and motor timing, recent evidence suggests that it also plays a role in nonmotor psychological processes. Indeed, cerebellar anomalies in schizophrenia have been linked to cognitive dysfunction and poor long-term outcome. To test the hypothesis that schizophrenia is associated with cerebellar dysfunction, cerebellar-dependent, delay eye-blink conditioning was examined in 62 individuals with schizophrenia and 62 age-matched non-psychiatric comparison subjects. The conditioned stimulus was a 400 ms tone, which co-terminated with a 50 ms unconditioned stimulus air puff. A subset of participants (25 with schizophrenia and 29 controls) also completed the Wechsler Abbreviated Scale of Intelligence. Participants with schizophrenia exhibited lower rates of eye-blink conditioning, including earlier (less adaptively timed) conditioned response latencies. Cognitive functioning was correlated with the rate of conditioned responsing in the non-psychiatric comparison subjects but not among those with schizophrenia, and the magnitude of these correlations significantly differed between groups. These findings are consistent with models of schizophrenia in which disruptions within the cortico-cerebellar-thalamic-cortical (CCTC) brain circuit are postulated to underlie the cognitive fragmentation that characterizes the disorder.
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DOI：
10.1177/1534582302001003004
发表时间：
2002-09-01
期刊：
Behavioral and cognitive neuroscience reviews
影响因子：
--
作者：
Katz, Donald B;Steinmetz, Joseph E
通讯作者：
Steinmetz, Joseph E
影响因子：
3.3
作者：
Eastwood, SL;Cotter, D;Harrison, PJ
通讯作者：
Harrison, PJ
影响因子：
9.9
作者：
Hermann, B;Seidenberg, M;Dow, C
通讯作者：
Dow, C
影响因子：
2.3
作者：
Edwards, Chad R.;Newman, Sharlene;Hetrick, William P.
通讯作者：
Hetrick, William P.
影响因子：
4.5
作者：
Friston, KJ
通讯作者：
Friston, KJ