Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats.
Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats.
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DOI：
10.1007/s00213-014-3561-y
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发表时间：
2014-10
影响因子：
3.4
通讯作者：
McDougall, Sanders A.
中科院分区：
文献类型：
--
作者：
Mohd-Yusof, Alena;Gonzalez, Ashley E.;Veliz, Ana;McDougall, Sanders A.
介导行为致敏个体发生的神经机制尚不清楚。本研究的目的是确定D1受体在断奶前诱导多巴胺激动剂诱导的行为致敏中的作用。在第一个实验中，通过在出生后第12、16、20或24天（PD）将雄性和雌性大鼠置于活动室之前，用生理盐水或NPA（0.5、1或2 mg/kg， IP）预处理雄性和雌性大鼠，研究了NPA诱导的行为致敏的早期个体发生。1天后，给大鼠低剂量NPA，观察运动致敏的发生情况。在随后的实验中，大鼠在可卡因、甲基苯丙胺或NPA预处理前0,15、30或60分钟注射生理盐水或D1受体拮抗剂SCH23390（0.1、0.5、1或5 mg/kg， IP）。第二天，大鼠再次使用相同的多巴胺激动剂进行测试，并评估致敏反应。NPA在所有年龄的测试中产生了一次试验的行为敏化。在断奶前大鼠中，无论剂量如何，SCH23390都不能有效预防可卡因、甲基苯丙胺或npa诱导的单试验行为致敏。目前的结果与成年啮齿动物的研究部分相反，在研究中，SCH23390阻断了甲基苯丙胺和阿帕吗啡诱导的行为致敏，但不阻断可卡因致敏。综合考虑这些发现，D1受体刺激似乎不是断奶前诱导行为敏感的必要条件，尽管D1受体在成年期可能发挥更重要的作用。
The neural mechanisms mediating the ontogeny of behavioral sensitization are poorly understood. The purpose of the present study was to determine the role of the D1 receptor for the induction of dopamine agonist-induced behavioral sensitization during the preweanling period. In the first experiment, the early ontogeny of NPA-induced behavioral sensitization was examined by pretreating male and female rats with saline or NPA (0.5, 1, or 2 mg/kg, IP) before placement in activity chambers on postnatal day (PD) 12, 16, 20, or 24. One day later, rats were tested with lower doses of NPA and the occurrence of locomotor sensitization was determined. In subsequent experiments, rats were injected with saline or the D1 receptor antagonist SCH23390 (0.1, 0.5, 1, or 5 mg/kg, IP) 0, 15, 30, or 60 min before cocaine, methamphetamine (METH), or NPA pretreatment. The next day, rats were tested with the same dopamine agonist again and sensitized responding was assessed. NPA produced one-trial behavioral sensitization at all ages tested. In preweanling rats, SCH23390, regardless of dose, was ineffective at preventing the induction of cocaine-, METH-, or NPA-induced one-trial behavioral sensitization. The present results are in partial contrast to adult rodent studies, in which SCH23390 blocks the induction of METH- and apomorphine-induced behavioral sensitization, but not cocaine sensitization. When these findings are considered together, it appears that D1 receptor stimulation is not necessary for the induction of behavioral sensitization during the preweanling period, although D1 receptors may play a more important role in adulthood.
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影响因子：
3.4
作者：
KURIBARA, H
通讯作者：
KURIBARA, H
影响因子：
3.4
作者：
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通讯作者：
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作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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