Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish.
Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish.
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DOI：
10.3389/fphar.2014.00153
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发表时间：
2014
影响因子：
5.6
通讯作者：
Kokel D
中科院分区：
文献类型：
--
作者：
Bruni G;Lakhani P;Kokel D
大多数神经活性药物是通过意外的行为观察发现的。系统的行为筛选在大多数模式生物中是低效的。但是，自动化技术正在使中枢神经系统（CNS）药理学研究进入一个新的阶段。研究人员正在斑马鱼中使用大规模的基于行为的化学筛选，以发现具有新结构，目标和功能的化合物。这些化合物是了解CNS信号通路的有力工具。人类和斑马鱼生物学之间的巨大差异将使这些发现难以转化为临床医学。然而，考虑到人类和斑马鱼之间的分子遗传相似性，这些化合物中的一些可能具有翻译实用性。我们预测，CNS药物发现的最大新成功将利用许多模型系统，包括体外试验，细胞，啮齿动物和斑马鱼。
Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behavioral screening is inefficient in most model organisms. But, automated technologies are enabling a new phase of discovery-based research in central nervous system (CNS) pharmacology. Researchers are using large-scale behavior-based chemical screens in zebrafish to discover compounds with new structures, targets, and functions. These compounds are powerful tools for understanding CNS signaling pathways. Substantial differences between human and zebrafish biology will make it difficult to translate these discoveries to clinical medicine. However, given the molecular genetic similarities between humans and zebrafish, it is likely that some of these compounds will have translational utility. We predict that the greatest new successes in CNS drug discovery will leverage many model systems, including in vitro assays, cells, rodents, and zebrafish.
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影响因子：
7
作者：
Auer TO;Duroure K;De Cian A;Concordet JP;Del Bene F
通讯作者：
Del Bene F
影响因子：
3.5
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通讯作者：
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DOI：
10.1007/s12265-010-9214-6
发表时间：
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通讯作者：
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