Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in rats.
Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in rats.
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DOI：
10.1111/j.1460-9568.2009.06705.x
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Kantak KM
中科院分区：
文献类型：
--
作者：
Mashhoon Y;Tsikitas LA;Kantak KM
Research with dopamine D1 receptor antagonists or neuronal inactivating agents suggests dissociable regulation of cocaine-seeking behavior by the rostral and caudal basolateral amygdala. In the present study, discrete infusions of the D1 receptor agonist SKF 81297 (0.0–0.8 μg/side) were compared to the D1 receptor antagonist SCH 23390 (0.0–2.0 μg/side) to demonstrate directly the importance of D1 receptor mechanisms within the rostral and caudal basolateral amygdala for their functional heterogeneity in regulating cocaine-seeking behavior. Under a second-order schedule, cocaine-seeking behavior was studied during maintenance (cocaine and cocaine cues present) and reinstatement (only cocaine cues present). Food-maintained responding examined specificity of maximal behaviorally effective doses of SKF 81297 and SCH 23390. Results demonstrated that the D1 agonist (0.4 or 0.8 μg) increased and D1 antagonist (1.0 μg) decreased cocaine-seeking behavior during maintenance when infused into caudal but not rostral basolateral amygdala. Cocaine intake was not affected by the agonist and was decreased by the antagonist. During reinstatement, the D1 agonist (0.4 μg) increased and D1 antagonist (1.0 μg) decreased cocaine-seeking behavior when infused into rostral but not caudal basolateral amygdala. In tests for behavioral specificity, the above effective doses of SKF 81297 and SCH 23390 used in self-administration experiments did not alter food-maintained responding. However, the 2.0 μg dose of SCH 23390 suppressed drug- and food-maintained responding after infusion into both subregions. Collectively, findings indicate dissociable sensitivity to D1 receptor ligands within the caudal and rostral basolateral amygdala for altering cocaine-seeking behavior under different conditions modeling phases of addiction.
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影响因子：
3.4
作者：
McLaughlin, J;See, RE
通讯作者：
See, RE
影响因子：
25
作者：
Ito, R;Robbins, TW;Everitt, BJ
通讯作者：
Everitt, BJ
DOI：
10.1073/pnas.98.4.1976
发表时间：
2001-02-13
影响因子：
11.1
作者：
Ciccocioppo, R;Sanna, PP;Weiss, F
通讯作者：
Weiss, F
影响因子：
3.4
作者：
Di Pietro, Nina C.;Black, Yolanda D.;Kantak, Kathleen M.
通讯作者：
Kantak, Kathleen M.
影响因子：
--
作者：
Everitt, BJ;Dickinson, A;Robbins, TW
通讯作者：
Robbins, TW