Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes.
Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes.
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DOI：
10.1126/science.aar4142
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发表时间：
2018-06-08
期刊：
影响因子：
--
通讯作者：
Jin H
中科院分区：
文献类型：
--
作者：
Cai Q;Qiao L;Wang M;He B;Lin FM;Palmquist J;Huang SD;Jin H
一些病原体和害虫将小rna （sRNAs）传递到宿主细胞中以抑制宿主免疫。相反，宿主也会将srna转移到病原体和害虫中以抑制它们的毒力。尽管在各种相互作用中已经观察到sRNA运输，但sRNA如何转移，特别是如何从宿主转移到病原体和害虫，仍然未知。在这里，我们发现宿主拟南芥细胞分泌外泌体样细胞外囊泡，将sRNAs传递到真菌病原体灰葡萄球菌中。这些含有srna的囊泡积聚在感染部位并被真菌细胞吸收。转移的宿主sRNAs诱导真菌致病性关键基因的沉默。因此，在与病原体的进化军备竞赛中，拟南芥已经适应了外泌体介导的跨界RNA干扰作为其免疫反应的一部分。
Some pathogens and pests deliver small RNAs (sRNAs) into host cells to suppress host immunity. Conversely, hosts also transfer sRNAs into pathogens and pests to inhibit their virulence. Although sRNA trafficking has been observed in a wide variety of interactions, how sRNAs are transferred, especially from hosts to pathogens and pests, is still unknown. Here, we show that host Arabidopsis cells secrete exosome-like extracellular vesicles to deliver sRNAs into fungal pathogen Botrytis cinerea. These sRNA-containing vesicles accumulate at the infection sites and are taken up by the fungal cells. Transferred host sRNAs induce silencing of fungal genes critical for pathogenicity. Thus, Arabidopsis has adapted exosome-mediated cross-kingdom RNA interference as part of its immune responses during the evolutionary arms race with the pathogen.
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影响因子：
10.5
作者：
Catalanotto, C;Azzalin, G;Cogoni, C
通讯作者：
Cogoni, C
影响因子：
9.5
作者：
Wang M;Thomas N;Jin H
通讯作者：
Jin H
DOI：
10.1073/pnas.0506426102
发表时间：
2005-09-06
影响因子：
11.1
作者：
Xie, ZX;Allen, E;Carrington, JC
通讯作者：
Carrington, JC
影响因子：
30.3
作者：
LaMonte G;Philip N;Reardon J;Lacsina JR;Majoros W;Chapman L;Thornburg CD;Telen MJ;Ohler U;Nicchitta CV;Haystead T;Chi JT
通讯作者：
Chi JT
影响因子：
6.7
作者：
Liu Y;Mittal R;Solis NV;Prasadarao NV;Filler SG
通讯作者：
Filler SG