Genes Involved in the Production of Antimetabolite Toxins by Pseudomonas syringae Pathovars.

Genes Involved in the Production of Antimetabolite Toxins by Pseudomonas syringae Pathovars.
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DOI:
10.3390/genes2030640
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发表时间:
2011-09-15
期刊:
影响因子:
3.5
通讯作者:
Vicente Ad
Vicente Ad
中科院分区:
生物学3区
文献类型:
--
作者:
Arrebola E;Cazorla FM;Pérez-García A;Vicente Ad

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假单胞菌在多种植物中是致病性的,引起具有经济影响的疾病。假单胞菌致病变种产生几种毒素,可以作为毒力因子发挥作用,并有助于疾病症状。这些毒力因子包括抗代谢毒素,如tabtoxin、phaseolotoxin和mangotoxin,其靶向氨基酸代谢途径中的酶。抗代谢毒素通常位于特定菌株的柔性基因组中存在的基因簇中。这些基因簇通常存在于基因块中,这些基因块似乎被整合到P.lingae核心基因组的特定位点中。在本工作中,将给出抗代谢毒素的遗传组织和这些遗传性状的生物合成和调节功能的一般概述。
Pseudomonas syringae is pathogenic in a wide variety of plants, causing diseases with economic impacts. Pseudomonas syringae pathovars produce several toxins that can function as virulence factors and contribute to disease symptoms. These virulence factors include antimetabolite toxins, such as tabtoxin, phaseolotoxin and mangotoxin, which target enzymes in the pathways of amino acid metabolism. The antimetabolite toxins are generally located in gene clusters present in the flexible genomes of specific strains. These gene clusters are typically present in blocks of genes that appear to be integrated into specific sites in the P. syringae core genome. A general overview of the genetic organization and biosynthetic and regulatory functions of these genetic traits of the antimetabolite toxins will be given in the present work.
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发表时间: 1992-09-01
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