Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles.
Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles.
复制标题
长时间预防视网膜胺的纳米颗粒进行视网膜变性。
DOI：
10.1016/j.biomaterials.2014.12.019
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发表时间：
2015-03
期刊：
影响因子：
14
通讯作者：
Lu, Zheng-Rong
中科院分区：
文献类型：
--
作者：
Puntel, Anthony;Maeda, Akiko;Golczak, Marcin;Gao, Song-Qi;Yu, Guanping;Palczewski, Krzysztof;Lu, Zheng-Rong
视网膜变性损害了全世界各个年龄段数百万人的视力。越来越多的证据表明，许多视网膜退行性疾病的病因与视觉循环中涉及的生化反应受损有关，视觉循环是负责视觉发色团（11-顺式-视网膜）再生的代谢途径。有毒类视黄醇代谢物，尤其是全反式视黄醛的清除效率低下，被认为是光感受器细胞毒性的原因。伯胺，包括视黄胺，可有效降低视网膜内全反式视网膜的浓度，从而预防人类视网膜病小鼠模型的视网膜变性。在这里，我们通过聚乳酸纳米粒子向 Abca4−/−Rdh8−/− (DKO) 小鼠（斯塔加特病/年龄相关性黄斑变性的动物模型）的眼睛受控递送视黄胺，实现了视网膜变性的长期预防。皮下注射含有视黄胺的纳米颗粒可以为眼睛持续提供大约一周的药物，并能有效长期预防 DKO 小鼠光诱导的视网膜变性。视黄胺纳米颗粒有望长期预防性治疗人类视网膜退行性疾病，包括斯塔加特病和年龄相关性黄斑变性。
Retinal degeneration impairs the vision of millions in all age groups worldwide. Increasing evidence suggests that the etiology of many retinal degenerative diseases is associated with impairment in biochemical reactions involved in the visual cycle, a metabolic pathway responsible for regeneration of the visual chromophore (11-cis-retinal). Inefficient clearance of toxic retinoid metabolites, especially all-trans-retinal, is considered responsible for photoreceptor cytotoxicity. Primary amines, including retinylamine, are effective in lowing the concentration of all-trans-retinal within the retina and thus prevent retina degeneration in mouse models of human retinopathies. Here we achieved prolonged prevention of retinal degeneration by controlled delivery of retinylamine to the eye from polylactic acid nanoparticles in Abca4−/−Rdh8−/− (DKO) mice, an animal model of Stargardt disease/age-related macular degeneration. Subcutaneous administration of the nanoparticles containing retinylamine provided a constant supply of the drug to the eye for about a week and resulted in effective prolonged prevention of light-induced retinal degeneration in DKO mice. Retinylamine nanoparticles hold promise for prolonged prophylactic treatment of human retinal degenerative diseases, including Stargardt disease and age-related macular degeneration.
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影响因子：
3.7
作者：
Gaudana R;Jwala J;Boddu SH;Mitra AK
通讯作者：
Mitra AK
影响因子：
4.8
作者：
Rattner, A;Smallwood, PM;Nathans, J
通讯作者：
Nathans, J
影响因子：
4.8
作者：
Maeda, Akiko;Maeda, Tadao;Palczewski, Krzysztof
通讯作者：
Palczewski, Krzysztof
影响因子：
1.8
作者：
Sparrow, JR;Fishkin, N;Nakanishi, K
通讯作者：
Nakanishi, K
使用可降解的聚合物纳米颗粒的超支多甘油涂层对药物输送的影响。
影响因子：
14
作者：
Deng, Yang;Saucier-Sawyer, Jennifer K.;Hoimes, Christopher J.;Zhang, Junwei;Seo, Young-Eun;Andrejecsk, Jillian W.;Saltzman, W. Mark
通讯作者：
Saltzman, W. Mark