Transcranial ultrasound stimulation effect in the redundant and synergistic networks consistent across macaques

Transcranial ultrasound stimulation effect in the redundant and synergistic networks consistent across macaques
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冗余和协同网络中的经颅超声刺激效果在猕猴中一致

DOI:
10.1101/2023.11.02.564776
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发表时间:
2023
期刊:
--
影响因子:
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通讯作者:
Gatica M
Gatica M
中科院分区:
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文献类型:
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作者:
Gatica M

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低强度经颅超声刺激(TUS)是一种非侵入性技术,可以安全地改变神经活动,以良好的空间准确性到达脑深部区域。我们研究了TUS在猕猴使用最近的度量,协同减冗余秩梯度,它量化了不同种类的神经信息处理的影响。我们分析了TUS后两个目标的fMRI数据的高阶量:辅助运动区(SMA-TUS)和额叶极皮层(FPC-TUS)。TUS在FPC-TUS的边缘网络和SMA-TUS的运动网络产生了特定的变化,并改变了这两个目标的感觉运动、颞叶和额叶网络,在猕猴中大部分是一致的。此外,在两种刺激后,结构和功能耦合减少。最后,TUS改变了固有的高阶网络拓扑结构,减少了SMA-TUS的冗余模块化组织,增加了FPC-TUS的协同集成。
Low-intensity transcranial ultrasound stimulation (TUS) is a noninvasive technique that safely alters neural activity, reaching deep brain areas with good spatial accuracy. We investigated the effects of TUS in macaques using a recent metric, the synergy minus redundancy rank gradient, which quantifies different kinds of neural information processing. We analyzed this high-order quantity on the fMRI data after TUS in two targets: the supplementary motor area (SMA-TUS) and the frontal polar cortex (FPC-TUS). The TUS produced specific changes at the limbic network at FPC-TUS and the motor network at SMA-TUS and altered the sensorimotor, temporal, and frontal networks in both targets, mostly consistent across macaques. Moreover, there was a reduction in the structural and functional coupling after both stimulations. Finally, the TUS changed the intrinsic high-order network topology, decreasing the modular organization of the redundancy at SMA-TUS and increasing the synergistic integration at FPC-TUS.
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