Cyclodepsipeptides: a rich source of biologically active compounds for drug research.
Cyclodepsipeptides: a rich source of biologically active compounds for drug research.
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DOI：
10.3390/molecules190812368
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发表时间：
2014-08-15
期刊：
影响因子：
--
通讯作者：
Scherkenbeck J
中科院分区：
文献类型：
--
作者：
Sivanathan S;Scherkenbeck J
面对寻找治疗各种疾病的新药的需求，科学发现自然界提供了许多种类的化合物，这些化合物显示出令人印象深刻的高生物潜力。其中包括环缩肽，由氨基酸和羟基酸组成的混合结构。在过去的几十年中，许多环缩肽已被分离，其作为药物的潜力已被广泛研究。对于几个cyclodepsipeptides全合成在溶液中和固相已经建立，允许生产组合库。此外，特定环缩酚肽的生物合成已被阐明，并用于非天然类似物的化学酶制剂。本文综述了近年来有关α-氨基酸和α-羟基酸组成的环状四肽至十肽的文献。
Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerous cyclodepsipeptides have been isolated and their potential as drugs has been studied extensively. For several cyclodepsipeptides total syntheses both in solution and on solid-phase have been established, allowing the production of combinatorial libraries. In addition, the biosynthesis of specific cyclodepsipeptides has been elucidated and used for the chemoenzymatic preparation of nonnatural analogues. This review summarizes the recent literature on cyclic tetra- to decadepsipeptides, composed exclusively of α-amino- and α-hydroxy acids.
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