Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism.
Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism.
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DOI：
10.3389/fncel.2014.00397
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发表时间：
2014
影响因子：
5.3
通讯作者：
Casanova MF
中科院分区：
文献类型：
--
作者：
Casanova EL;Casanova MF
自闭症的尸检神经病理学研究一致揭示了不同类型的畸形，包括皮质发育不良、异位畸形和各种神经形态测量异常。为了与这些观察保持一致，我们在这里回顾了88%的自闭症高危基因影响神经诱导和神经母细胞的早期成熟。此外，这些相同的基因中有80%影响分化的后期阶段，包括神经突和突触发育，这表明这些基因产物对细胞发育以及神经增殖，生长和成熟过程中的冗余元素表现出持久的发育作用。我们还讨论了自闭症与癫痫和精神分裂症等疾病的假定遗传重叠，以及对共同和不同病因的影响。这篇评论进口的必要性，移码在我们的理解自闭症的神经发育基础，包括所有阶段的神经元成熟，从神经诱导突触。
Postmortem neuropathological studies of autism consistently reveal distinctive types of malformations, including cortical dysplasias, heterotopias, and various neuronomorphometric abnormalities. In keeping with these observations, we review here that 88% of high-risk genes for autism influence neural induction and early maturation of the neuroblast. In addition, 80% of these same genes influence later stages of differentiation, including neurite and synapse development, suggesting that these gene products exhibit long-lasting developmental effects on cell development as well as elements of redundancy in processes of neural proliferation, growth, and maturation. We also address the putative genetic overlap of autism with conditions like epilepsy and schizophrenia, with implications to shared and divergent etiologies. This review imports the necessity of a frameshift in our understanding of the neurodevelopmental basis of autism to include all stages of neuronal maturation, ranging from neural induction to synaptogenesis.
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