USP2-Related Cellular Signaling and Consequent Pathophysiological Outcomes.
USP2-Related Cellular Signaling and Consequent Pathophysiological Outcomes.
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DOI：
10.3390/ijms22031209
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发表时间：
2021-01-26
影响因子：
5.6
通讯作者：
Hashimoto M
中科院分区：
文献类型：
--
作者：
Kitamura H;Hashimoto M
泛素特异性蛋白酶（USP）2是一种多功能去泛素化酶。USP 2通过细胞周期蛋白和Aurora-A的去泛素化调节细胞周期进程，从而调节致癌作用。其他致瘤分子，包括表皮生长因子和脂肪酸合酶，也是USP 2的靶点。USP 2还阻止p53信号传导。另一方面，USP 2作为CLOCK/BMAL 1复合物的关键组分发挥作用，并参与视交叉上核和肝脏中的节律性基因表达。USP 2变异体通过控制肝细胞生成、肝胆固醇摄取、脂肪组织炎症和随后的全身胰岛素敏感性来影响能量代谢。USP 2还具有促进肾和肠上皮细胞中离子通道的表面表达的潜力。除了改变免疫细胞中细胞因子的产生外，USP 2还调节参与靶细胞中细胞因子信号传导的信号分子。Usp 2基因敲除小鼠表现出运动和雄性生育力的变化，这表明USP 2分别在中枢神经系统和雄性生殖道中的作用。在这篇综述中，我们总结了与USP 2的贡献的细胞事件，并列出了信号分子的上游或下游的USP 2。此外，我们描述了在体外和体内实验模型中发现的表型差异。
Ubiquitin specific protease (USP) 2 is a multifunctional deubiquitinating enzyme. USP2 modulates cell cycle progression, and therefore carcinogenesis, via the deubiquitination of cyclins and Aurora-A. Other tumorigenic molecules, including epidermal growth factor and fatty acid synthase, are also targets for USP2. USP2 additionally prevents p53 signaling. On the other hand, USP2 functions as a key component of the CLOCK/BMAL1 complex and participates in rhythmic gene expression in the suprachiasmatic nucleus and liver. USP2 variants influence energy metabolism by controlling hepatic gluconeogenesis, hepatic cholesterol uptake, adipose tissue inflammation, and subsequent systemic insulin sensitivity. USP2 also has the potential to promote surface expression of ion channels in renal and intestinal epithelial cells. In addition to modifying the production of cytokines in immune cells, USP2 also modulates the signaling molecules that are involved in cytokine signaling in the target cells. Usp2 knockout mice exhibit changes in locomotion and male fertility, which suggest roles for USP2 in the central nervous system and male genital tract, respectively. In this review, we summarize the cellular events with USP2 contributions and list the signaling molecules that are upstream or downstream of USP2. Additionally, we describe phenotypic differences found in the in vitro and in vivo experimental models.
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影响因子：
4.4
作者：
Boustani, Mohammad Reza;Khoshnood, Reza Jalili;Goudarzi, Peyman Karimi
通讯作者：
Goudarzi, Peyman Karimi
影响因子：
6.2
作者：
Alonso, Veronica;Magyar, Clara E.;Wang, Bin;Bisello, Alessandro;Friedman, Peter A.
通讯作者：
Friedman, Peter A.
影响因子：
9
作者：
通讯作者：
--
影响因子：
4.4
作者：
Back, Songhee;Gorman, Andrew W.;Silva, Gustavo M.
通讯作者：
Silva, Gustavo M.
DOI：
10.1002/ajmg.b.31106
发表时间：
2010-10-05
影响因子：
2.8
作者：
Bousman, Chad A.;Chana, Gursharan;Glatt, Stephen J.;Chandler, Sharon D.;May, Todd;Lohr, James;Kremen, William S.;Tsuang, Ming T.;Everall, Ian P.
通讯作者：
Everall, Ian P.