DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
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DOI：
10.3945/ajcn.112.048462
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Hennig BJ
中科院分区：
文献类型：
--
作者：
Dominguez-Salas P;Moore SE;Cole D;da Costa KA;Cox SE;Dyer RA;Fulford AJ;Innis SM;Waterland RA;Zeisel SH;Prentice AM;Hennig BJ
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural variations in dietary intake of nutrients involved in methyl-donor pathways and their effect on the respective metabolic biomarkers. Design: In 30 women of reproductive age (18–45 y), we monitored diets monthly for 1 y by using 48-h weighed records to measure intakes of choline, betaine, folate, methionine, riboflavin, and vitamins B-6 and B-12. Blood biomarkers of these nutrients, S-adenosylhomocysteine (SAH), S-adenosylmethionine (SAM), homocysteine, cysteine, and dimethylglycine were also assessed monthly. Results: Dietary intakes of riboflavin, folate, choline, and betaine varied significantly by season; the most dramatic variation was seen for betaine. All metabolic biomarkers showed significant seasonality, and vitamin B-6 and folate had the highest fluctuations. Correlations between dietary intakes and blood biomarkers were found for riboflavin, vitamin B-6, active vitamin B-12 (holotranscobalamin), and betaine. We observed a seasonal switch between the betaine and folate pathways and a probable limiting role of riboflavin in these processes and a higher SAM/SAH ratio during the rainy season. Conclusions: Naturally occurring seasonal variations in food-consumption patterns have a profound effect on methyl-donor biomarker status. The direction of these changes was consistent with previously reported differences in methylation of metastable epialleles. This trial was registered at www.clinicaltrials.gov as NCT01811641.
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DOI：
10.1017/s0029665111003338
发表时间：
2012-02
期刊：
The Proceedings of the Nutrition Society
影响因子：
--
作者：
Dominguez-Salas P;Cox SE;Prentice AM;Hennig BJ;Moore SE
通讯作者：
Moore SE
影响因子：
7.1
作者：
Green, Ralph
通讯作者：
Green, Ralph
影响因子：
7.1
作者：
BLOCK, G;HARTMAN, AM
通讯作者：
HARTMAN, AM
影响因子：
7.1
作者：
Innis, Sheila M.;Davidson, A. George F.;James, S. Jill
通讯作者：
James, S. Jill
影响因子：
9.3
作者：
Moat, SJ;Ashfield-Watt, PAL;McDowell, IFW
通讯作者：
McDowell, IFW