Reduction of left ventricular longitudinal global and segmental systolic functions in patients with hypertrophic cardiomyopathy: Study of two-dimensional tissue motion annular displacement.
Reduction of left ventricular longitudinal global and segmental systolic functions in patients with hypertrophic cardiomyopathy: Study of two-dimensional tissue motion annular displacement.
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肥厚型心肌病患者左心室纵向整体和节段收缩功能的降低：二维组织运动环形位移的研究
DOI：
10.3892/etm.2014.1617
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发表时间：
2014-06
影响因子：
2.7
通讯作者：
Ge S
中科院分区：
文献类型：
--
作者：
Liu L;Tuo S;Zhang J;Zuo L;Liu F;Hao L;Sun Y;Yang L;Shao H;Qi W;Zhou X;Ge S
肥厚型心肌病（HCM）患者左室收缩功能异常的早期检测仍然是一个挑战。本研究的目的是确定一种新的方法来评估肥厚型心肌病患者的左心室收缩功能。本研究共纳入65例HCM患者。将患者分为梗阻性HCM组（HOCM; 16例）和非梗阻性HCM组（NOHCM; 49例）。健康对照组由48名参与者组成。采用二维斑点追踪技术测量左心室整体和节段纵向应变及二尖瓣环位移。与健康对照组相比，HOCM组和NOHCM组左室6个节段应变和整体应变（LSglobal）增加，二尖瓣环6个节段MAD和MADglobal减少（P<0.05）。此外，二尖瓣环6个节段的MAD与左心室6个节段的应变呈显著负相关（r=-0.744 ~-0.647，P<0.001）。MADglobal与LS global呈显著负相关（r=-0.857，P<0.001）。中点处的组织运动瓣环位移（TMAD）与LS global呈显著负相关（r=-0.871，P<0.001）。二维TMAD技术测量MAD可快速评价肥厚型心肌病患者左室纵向整体和节段收缩功能。
The early detection of abnormal left ventricular systolic functions in patients with hypertrophic cardiomyopathy (HCM) remains a challenge. The aim of this study was to identify a novel method for the assessment of left ventricular systolic function in patients with HCM. A total of 65 patients with HCM were included in this study. The patients were divided into obstructive HCM (HOCM; 16 cases) and non-obstructive HCM (NOHCM; 49 cases) groups. The healthy control group comprised 48 participants. Two-dimensional (2D) speckle-tracking technology was used to measure the left ventricular global and segmental longitudinal strains and mitral annular displacement (MADs). Compared with healthy control group, the six segmental strains and the global strain of the left ventricle (LSglobal) increased while six segmental MADs and MADglobal of the mitral annulus decreased in the HOCM and NOHCM groups (P<0.05). In addition, the six segmental MADs of the mitral annulus were significantly negatively correlated with the six segmental strains of the left ventricle (r=−0.744 to −0.647, P<0.001). MADglobal was significantly negatively correlated with LSglobal (r=−0.857, P<0.001). The tissue motion annular displacement (TMAD) at the midpoint was significantly negatively correlated with LSglobal (r=−0.871, P<0.001). The 2D TMAD technique of measuring MAD was feasible and practically approachable for rapidly evaluating the left ventricular longitudinal global and segmental systolic functions of patients with HCM.
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影响因子：
37.8
作者：
MARON, BJ;GARDIN, JM;BILD, DE
通讯作者：
BILD, DE
影响因子：
3.2
作者：
Ballo, Piercarlo;Barone, Daniele;Mondillo, Sergio
通讯作者：
Mondillo, Sergio
DOI：
10.1016/s0735-1097(87)80264-4
发表时间：
1987-10-01
影响因子：
24
作者：
MARON, BJ;SPIRITO, P;ARCE, J
通讯作者：
ARCE, J
影响因子：
24
作者：
Gersh, Bernard J.;Maron, Barry J.;Yancy, Clyde W.
通讯作者：
Yancy, Clyde W.
影响因子：
24
作者：
Serri, K;Reant, P;Lafitte, S
通讯作者：
Lafitte, S