Immunogenetic factors associated with severe respiratory illness caused by zoonotic H1N1 and H5N1 influenza viruses.
Immunogenetic factors associated with severe respiratory illness caused by zoonotic H1N1 and H5N1 influenza viruses.
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DOI：
10.1155/2012/797180
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发表时间：
2012
影响因子：
--
通讯作者：
Keynan Y
中科院分区：
文献类型：
--
作者：
Juno J;Fowke KR;Keynan Y
继2009年H1N1流感大流行和H5N1病毒持续的零星禽传人之后，重点一直放在更好地了解严重流感感染的决定因素和发病机制上。目前的大部分文献都集中在病毒遗传学及其对宿主免疫力的影响以及严重感染的新风险因素（特别是在H1N1大流行期间）。然而，目前缺乏对易感性和严重呼吸道疾病的宿主遗传决定因素的了解。通过更好地定义遗传变异在流感感染中的作用，并确定损害宿主免疫反应或与保护相关的关键多态性，我们将能够更好地确定高危人群和治疗干预和疫苗的新靶点。本文将总结与pH1N1和H5N1感染的易感性或严重性相关的已知免疫遗传因素，并确定遗传途径和多态性的高度相关性，为未来的研究。
Following the 2009 H1N1 pandemic and ongoing sporadic avian-to-human transmission of H5N1 viruses, an emphasis has been placed on better understanding the determinants and pathogenesis of severe influenza infections. Much of the current literature has focused on viral genetics and its impact on host immunity as well as novel risk factors for severe infection (particularly within the H1N1 pandemic). An understanding of the host genetic determinants of susceptibility and severe respiratory illness, however, is currently lacking. By better defining the role of genetic variability in influenza infection and identifying key polymorphisms that impair the host immune response or correlate with protection, we will be able to better identify at-risk populations and new targets for therapeutic interventions and vaccines. This paper will summarize known immunogenetic factors associated with susceptibility or severity of both pH1N1 and H5N1 infections and will also identify genetic pathways and polymorphisms of high relevance for future study.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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Hugo Borja-Aburto, Victor
DOI：
10.1186/cc8208
发表时间：
2009
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bermejo-Martin JF;Ortiz de Lejarazu R;Pumarola T;Rello J;Almansa R;Ramírez P;Martin-Loeches I;Varillas D;Gallegos MC;Serón C;Micheloud D;Gomez JM;Tenorio-Abreu A;Ramos MJ;Molina ML;Huidobro S;Sanchez E;Gordón M;Fernández V;Del Castillo A;Marcos MA;Villanueva B;López CJ;Rodríguez-Domínguez M;Galan JC;Cantón R;Lietor A;Rojo S;Eiros JM;Hinojosa C;Gonzalez I;Torner N;Banner D;Leon A;Cuesta P;Rowe T;Kelvin DJ
通讯作者：
Kelvin DJ