COVID-19 Infection and Psychotic Experiences: Findings From the Healthy Minds Study 2020.
COVID-19 Infection and Psychotic Experiences: Findings From the Healthy Minds Study 2020.
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DOI：
10.1016/j.bpsgos.2021.05.005
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
DeVylder J
中科院分区：
文献类型：
--
作者：
Oh H;Schiffman J;Marsh J;Zhou S;Koyanagi A;DeVylder J
世界各地的临床报告都记录了COVID-19感染背景下的精神病;然而，尚未进行大规模流行病学研究来证实这种关联。我们分析了健康心理研究（N = 15，935;在2020年9月至12月期间进行）的数据，该研究对美国28所大学之一的学生进行在线管理。使用多变量logistic回归，我们检查了过去12个月内COVID-19感染/严重程度与精神病经历之间的关联，调整了年龄，性别，种族/民族，国际学生身份以及焦虑和抑郁。超过五分之一的分析样本报告了COVID-19感染，约六分之一的COVID-19感染学生报告了过去12个月的精神病经历。在加权多变量logistic回归模型中，COVID-19感染与具有精神病经历的显著更大几率相关（校正后的比值比1.36，95%CI 1.19-1.48）。与无症状相比，中度（校正比值比1.85，95% CI 1.03-3.31）或重度（校正比值比1.76，95% CI 1.11-2.77）症状与精神病经历的几率显著更高相关。在调整抑郁和焦虑因素后，这些相关性在统计学上变得不显著。住院与感染COVID-19的学生的精神病经历没有显著相关性。精神病经历与COVID-19感染有关，尽管在考虑焦虑和抑郁时，这种关联在很大程度上被削弱了。基于这一大学生样本的发现应该在大学环境之外复制，以确定精神病是否是COVID-19感染期间和之后的神经精神症状。
Clinical reports from across the world have documented psychosis in the context of COVID-19 infection; however, there has yet to be a large-scale epidemiological study to confirm this association. We analyzed data from the Healthy Minds Study (N = 15,935; conducted between September and December 2020), which was administered online to students attending one of 28 colleges in the United States. Using multivariable logistic regression, we examined the associations between COVID-19 infection/severity and psychotic experiences over the past 12 months, adjusting for age, gender, race/ethnicity, and international student status as well as anxiety and depression. More than one fifth of the analytic sample reported COVID-19 infection, and about one in six students with COVID-19 infection reported psychotic experiences over the past 12 months. In weighted multivariable logistic regression models, COVID-19 infection was associated with significantly greater odds of having psychotic experiences (adjusted odds ratio 1.36, 95% CI 1.19–1.48). Compared with being asymptomatic, having moderate (adjusted odds ratio 1.85, 95% CI 1.03–3.31) or severe (adjusted odds ratio 1.76, 95% CI 1.11–2.77) symptoms was associated with significantly greater odds of having psychotic experiences. These associations became statistically nonsignificant when adjusting for depression and anxiety. Hospitalization was not significantly associated with psychotic experiences among students with COVID-19 infection. Psychotic experiences are associated with COVID-19 infections, though much of the association is attenuated when accounting for anxiety and depression. Findings based on this sample of college students should be replicated outside of the college context to determine whether psychosis is a neuropsychiatric symptom during and after COVID-19 infection.
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影响因子：
4.5
作者：
Narita, Zui;Stickley, Andrew;DeVylder, Jordan
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