Sleep habits and susceptibility to the common cold.
Sleep habits and susceptibility to the common cold.
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DOI：
10.1001/archinternmed.2008.505
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发表时间：
2009-01-12
影响因子：
--
通讯作者：
Turner, Ronald B.
中科院分区：
文献类型：
--
作者：
Cohen, Sheldon;Doyle, William J.;Alper, Cuneyt M.;Janicki-Deverts, Denise;Turner, Ronald B.
睡眠质量被认为是一个重要的预测免疫力，反过来对普通感冒的易感性。这篇文章探讨了病毒暴露前几周的睡眠时间和效率是否与感冒易感性有关。参与者是153名健康的男性和女性志愿者，年龄在21-55岁之间。在连续14天的时间里，他们报告了前一天晚上的睡眠时间和睡眠效率（实际睡眠时间的百分比），以及他们是否感到休息。在14天的基线上计算每个睡眠变量的平均得分。随后，参与者接受含有鼻病毒的鼻滴药，并在暴露前一天和暴露后五天内进行隔离和监测，以观察是否出现临床感冒（在存在客观疾病体征的情况下感染）。与平均睡眠时间有等级相关性，睡眠时间<7小时的人比睡眠时间≥ 8小时的人患感冒的可能性高2.94倍（CI[95%]=1.18-7.30）。与睡眠效率的相关性也进行了分级，效率< 92%的人比效率≥ 98%的人患感冒的可能性高5.50倍（CI[95%]=2.08-14.48）。这些关系不能用攻毒前病毒特异性抗体、人口统计学、一年中的季节、体重、社会经济状况、心理变量或健康实践的差异来解释。感觉休息的天数百分比与感冒无关。在暴露于鼻病毒之前的几周内，睡眠效率低和睡眠时间短与对疾病的抵抗力较低有关。
Sleep quality is thought to be an important predictor of immunity and in turn susceptibility to the common cold. This article examines whether sleep duration and efficiency in the weeks preceding viral exposure are associated with cold susceptibility. Participants were 153 healthy men and women volunteers, ages 21–55. For 14 consecutive days, they reported their sleep duration and sleep efficiency (percent of time in bed actually asleep) for the previous night, and whether they felt rested. Average scores for each sleep variable were calculated over the 14-day baseline. Subsequently, participants were administered nasal drops containing a rhinovirus, quarantined and monitored on the day before and for five days following exposure for development of a clinical cold (infection in the presence of objective signs of illness). There was a graded association with average sleep duration, with those with <7 hours sleep 2.94 times (CI[95%]=1.18–7.30) more likely to develop a cold than those with ≥ 8 hours. The association with sleep efficiency was also graded with those with < 92% efficiency 5.50 times (CI[95%]=2.08–14.48) more likely to develop a cold than those with efficiencies ≥98%. These relations could not be explained by differences in pre-challenge virus-specific antibody, demographics, season of the year, body mass, socioeconomic status, psychological variables or health practices. Percent of days feeling rested was not associated with colds. Poorer sleep efficiency and shorter sleep duration in the weeks preceding an exposure to a rhinovirus were associated with lower resistance to illness.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1001/jama.277.24.1940
发表时间：
1997-01-01
期刊：
JAMA (Journal of the American Medical Association)
影响因子：
--
作者：
Cohen, Sheldon;Doyle, William J.;Gwaltney, Jack M., Jr.
通讯作者：
Gwaltney, Jack M., Jr.
影响因子：
158.5
作者：
COHEN, S;TYRRELL, DAJ;SMITH, AP
通讯作者：
SMITH, AP
影响因子：
3.3
作者：
Cohen, Sheldon;Alper, Cuneyt M.;Turner, Ronald B.
通讯作者：
Turner, Ronald B.
影响因子：
--
作者：
Steptoe, Andrew;Peacey, Victoria;Wardle, Jane
通讯作者：
Wardle, Jane